The University of Southampton
Biological SciencesPostgraduate study
Email:
pi1g10@soton.ac.uk

Mr Paul Ibbett BSc

Postgraduate Research Student of Neuroinflammation

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Mr Paul Ibbett is Postgraduate Research Student of Neuroinflammation within Biological Sciences at the University of Southampton.

2010-2013: First class BSc (Hons) in Pharmacology. University of Southampton, UK.

In-depth research project: “Cysteine string protein-mutant C. elegans exhibit no significant phenotypic differences compared to wildtype in behavioural and pharmacological assays”

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Primary Research Group: CNS Inflammation Group
Affiliate Research Group: Southampton Neuroscience Group (SoNG)

Research Interests:
Neurodegenerative Diseases
Immunology

Age-related macular degeneration (AMD) is a common cause of blindness in the elderly. Both genetic and environmental factors are involved in the pathogenesis but the initiating factors are not known. Many clinical and experimental studies have concentrated on cellular and molecular changes in the retina and these studies have suggested that accumulation of debris-like material, or drusen, between the retinal pigment epithelium (RPE) and Bruch’s membrane, initiates an inflammatory response in the retina causing damage to RPE cells and photoreceptors. We hypothesise that chronic systemic inflammation also contributes to pathogenesis via activation of the retinal vasculature and macrophages/microglia. These events may result in increased local inflammation and cellular damage, especially in the presence of retinal pathology. This study aims to investigate the role of systemic inflammation by identifying a systemic immune signature for AMD. We propose to utilise a range of immune assays which are validated for detecting innate and adaptive immune activation in blood samples from patients with a chronic inflammatory disease. To dissect the underlying mechanism, we will use a model of immune-complex mediated retinal inflammation and test if systemic inflammation accelerates pathology. Immune activation will be further studied by blockade of two key pathways of innate and adaptive immunity, using neutralizing antibodies. Our proposal may provide insight into the pathogenesis of AMD but could also lead to novel or optimized therapeutic strategies by modulation of systemic inflammation.

Supervisor: Dr. Jessica Teeling, Prof. Hugh Perry, Prof. Andrew Lotery
PhD Research: The impact of systemic inflammation on age-related macular degeneration
Funding: Fight for Sight (UK)

Demonstrator:
BIOL2016 Pharmacology A
BIOL2017 Pharmacology B

Mr Paul Ibbett
Biological Sciences Mailpoint 840 (room LD30) Level D Laboratories and Pathology Block Southampton General Hospital Tremona Road Southampton SO16 6YD

Email:pi1g10@soton.ac.uk

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