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Biological SciencesPostgraduate study

Mr Yogendra Gaihre MSc (Nematology)

Postgraduate Research Student

Mr Yogendra Gaihre's photo

Yogendra Kumar Gaihre is a Postgraduate Research Student within Biological Sciences at University of Southampton.

He has done a Masters of Science in Nematology from the University of Ghent, Belgium. This Nematological training program provided him with a good opportunity to gain comprehensive knowledge of both plant parasitic nematodes (PPNs) and entomopathogenic nematodes (EPNs). The unavoidable fact that the plant parasitic nematodes pose a huge threat to global food security, especially in today’s world where most of the pesticides are restricted due to the negative effect they pose to human kind, made him enthusiastic, like others, to find a way to control the damage caused by these ill-famed creatures.

So little time, so much to do

Academic Qualifications

2016-present: PhD in Biological Sciences. University of Southampton, UK.
2008-2010: European Masters of Science in Nematology. University of Ghent, Belgium.
1997-2000: Masters of Science (Zoology). Tribhuwan University, Kathmandu, Nepal.

Research interests

Potato cyst nematode (PCN, Globodera sp.) is a major pest affecting global potato production that imposes an annual cost in excess of £50 million in UK alone. Problems in controlling PCN population are growing because of the increase in population, reduction in the use of pesticides due to the adverse effect they pose to human beings and lack of commercially available resistant cultivars. Some of the traditional approaches in tackling PCN includes sanitary and phytosanitary measures, crop rotation, soil solarisation, trap cropping, use of resistant cultivars, chemical and biological control methods.

PCN are stimulated to hatch in the field by the presence of potato root diffusate. In addition to all the approaches mentioned above, an alternative strategy could be the application of hatching stimuli prior to sowing, to promote ‘suicidal hatch’ where the free-living nematodes starve to death before coming in contact with potato crop. However, plants do not produce sufficient amount of hatching compounds, which could be extracted for the treatment in the field. Recent advances in chemical synthesis have now made the possibility of producing sufficient quantities a step closer.

Now, the time has come to characterize the profile of egg hatching compounds using phytochemical analysis methods in a range of diverse potato germplasm and correlate the levels with egg hatching potential using bioassay techniques. The outcome of this research will have a list of hatching compounds, which in case of being synthesized in the laboratories could fit the ‘suicidal hatch’ strategy in a better place in the integrated pest management.

As a research student, I am quite interested to a) identify and optimize potato root diffusate capture and fractionation methods and hatching factor compound analysis, b) identify and propagate potato germplasm with a wide range in the concentration of hatching factor compounds, c) comparative transcript profiling of potato accessions identified as containing high and low levels of hatching factor compounds, and d) develop novel microfluidic methods for nematode hatching bioassays to increase throughout. 

Supervisors: Prof. Lindy Holden-DyeProf. Vincent O’Connor & Prof. Hywel Morgan
PhD Research: Control of cyst nematodes by characterisation and manipulation of the biosynthesis of the egg hatching compounds
Funding: James Hutton Institute & University of Southampton

Research group

Environmental Biosciences

Biochemical Society
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Mr Yogendra Gaihre
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ

Room Number: 85/3041

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