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The University of Southampton
Biological Sciences

Research project: Calcium Pumps and Thermogenesis

Currently Active: 
Yes

We have recently shown that sarcolipin, a modulator of the sarcoplasmic reticulum pump, reduces the efficiency of calcium pumping resulting in heat generation.

We are investigating the mechanism by which this uncoupling of calcium transport is achieved. In addition, we are examining sarcolipin levels in muscle tissue to estimate the amount of heat that might be generated in humans by this route. Sarcolipin may play a role in thermogenesis and altering sarcolipin activity may provide a target for the development of antiobesity drugs.

Related research groups

Molecular and Cellular Biosciences
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