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The University of Southampton
Biological Sciences

Research project: Differentiation therapy and cancer

Currently Active: 
Yes

Many childhood cancers are caused by a failure to differentiate for instance neuroblastoma a childhood cancer of sympathetic nervous system arises when neural crest cells fail to differentiate. Agents that will induce neural crest diferentiation may therefore prove effective therapeutic agents for treatment of this cancer.

A number of recent studies have demonstrated that a variety of fatty acids are able to alter the proliferation of several types of tumour cells. We have shown that fatty acids that activate the ligand activated peroxisomal proliferator activated receptors (PPARs) and induce cell cycle arrest and morphological differentiation in human neuroblastoma cells. We are currently investigating whether specific ligands of the different PPAR isoforms are more potent inhibitors of neuroblastoma cell growth than fatty acids.

Related research groups

Molecular and Cellular Biosciences
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