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The University of Southampton
Biological Sciences

Research project: Does Wlds mediate protection in a Drosophila model of tauopathies?

Currently Active: 

Is axonal degeneration occurring in Alzheimer’s diseae and related tauopathies wallerian in nature?  

Axonal dysfunction due to cytoskeletal destabilisation is a characterising feature of neurodegenerative diseases such as Alzheimer’s Disease. Wlds is a mutation that protects against wallerian axonal degeneration, which also exhibits cytoskeletal destabilisation. This project is aimed at understanding whether axonal degeneration in Alzheimer’s disease is wallerian in nature, and if so, whether it can be protected by Wlds.

Funding: Gerald Kerkut Trust

Funding duration: October 2012-April 2015

Research Group Affiliation

Southampton Neuroscience Group


Related research groups

Biomedical Sciences
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