Research project: Investigating novel mechanisms bridging cell polarity, spindle orientation and chromosome dynamics in mitotic mammary epithelial cells
Oriented cell divisions (OCDs) in mammary epithelial cells represent a critical mechanism for cell fate decisions, epithelial maintenance and tissue morphogenesis, and their disruption has direct implications for breast cancer. This project uses a range of cellular and molecular and imaging techniques to uncover the precise mechanisms coordinating cell polarity and correct mitotic spindle assembly and orientation and chromosome dynamics to ensure proper epithelial architecture and differentiation.