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The University of Southampton
Biological Sciences

Research project: The regulation of epigenetic signalling by nuclear phosphoinositides

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Phosphoinositides are lipid messengers that are present in the nucleus. They interact with and regulate many proteins that are involved in modulating chromatin to impact on nuclear processes such as transcription, DNA repair and mRNA splicing and export. The project is aimed at understanding how nuclear phosphoinositides modulate histone modifications.

PIP5K is an lipid kinase that generates the phosphoinositide messenger PIP2. Canonically this lipid is hydrolysed by phospholipase C (PLC) to two new second messengers IP3, which regulates calcium and DAG which regulates PKC. In the nucleus besides being a substrate for PLC, PIP2 also directly regulates gene transcription and mRNA maturation by interacting with and regulating target proteins. We have identified a protein that interacts with PIP5K that is involved in regulating histone modifications and consequently transcription. We are trying to understand exactly how PIP5K and its product PIP2 impacts on the activity of this histone modifying complex and how this then regulates gene transcriptional output.

Funding: Biological Sciences
Funding Duration: 2014-2016

Related research groups

Biomedical Sciences
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