Research project: Unravelling the role of microtubule stabilisation in the pathogenesis of Alzheimer’s disease
Tau and Abeta are implicated in the pathogenesis of Alzheimer’s disease. The mechanisms by which they interact are unknown. This project focuses on exploring this. Microtubule destabilisation is believed to be a key mechanism by which phosphorylated tau causes dysfunction in tauopathies. In Alzheimer’s disease Abeta peptide toxicity is mediated by phosphorylated tau. This PhD project investigates whether microtubule destabilisation underpins this tau-Abeta interaction.