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The University of Southampton
Biological Sciences

Professor V Hugh Perry BSc, MA, DPhil.

Emeritus Professor of Experimental Neuropathology

Professor V Hugh Perry's photo

Professor V Hugh Perry is Emeritus Professor of Experimental Neuropathology within Biological Sciences at the University of Southampton.

Career history

2018-present: Emeritus Professor of Experimental Neuropathology. University of Southampton, UK.
Chair Neuroscience and Mental Health Board. MRC, UK.
Visiting Professor in the College of Medicine & Veterinary Medicine. University of Edinburgh, UK.
Professor of Experimental Neuropathology. University of Southampton, UK.
Professor of Experimental Neuropathology. University of Oxford, UK.
Locke Royal Society Research Fellow. UK.
Wellcome Trust Senior Research Fellow. UK.
Research Fellow. University of Oxford, UK.

Research interests

Inflammation in the CNS and its contribution to neurological Disease

The role of microglia in health and disease

The role of systemic inflammation in Alzheimer’s disease and other neurodegenerative diseases

Immune brain communication


Affiliate research groups

Institute for Life Sciences (IfLS), Southampton Neuroscience Group (SoNG)

Research project(s)

Systemic inflammation in progressive MS

In this project we are investigating whether systemic infections can contribute to driving the progression of the progressive phase of multiple sclerosis.

Immune-to-brain communication in immune-mediated lung inflammation; studies of neuronal mechanisms and the impact of immunomodulators

Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate the biological nature of immune-to-brain communication elicited by immune-mediated lung disease.

Inflammation in chronic neurodegeneration and the contribution of systemic inflammation

We are investigating the microglia activation in a model of prion disease, mouse scrapie.

Linking the immune system to the central nervous system: a role for antibodies and Fcγ receptors in neuronal damage.

Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate antibody-mediated neuronal damage in lupus.

The impact of systemic bacterial and viral infections on innate immune responses in the brain

Using immunocytochemistry, cell biology, imaging and formal behavioural testing techniques we investigate how systemic infections impact on the brain.

The role of IgG Fc receptors in the pathogenesis of age related macular degeneration and its implications for therapeutic intervention.

Using novel models for AMD, we will investigate the functional role of antibodies in disease onset and progression.

Understanding oligodendrocyte progenitor dynamics and myelin loss in Alzheimer’s Disease

Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease.

Does Wlds mediate protection in a Drosophila model of tauopathies?

Can Wlds protect against axonal dysfunction and degeneration in a transgenic model of Alzheimer’s disease?

Understanding microglial dynamics in the healthy and ageing brain

Microglial cells are the resident immune cells of the brain and play crucial roles in the regulation of normal and pathological neural functions. This PhD project aims at studying the balance of the numbers of microglial cells from development to ageing, to better understand the roles of these cells in the brain, through a multidisciplinary approach using in vivo models, genetic molecular tools and behavioural analysis of brain function.

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Book Chapters

  • Gomez-Nicola, D., & Perry, V. H. (2014). Neurodegenerative diseases. In M-E. Tremblay, & A. Sierra (Eds.), Microglia in Health and Disease (pp. 437-453). New York, US: Springer.
  • Fabriek, B. O., Galea, I., Perry, V. H., & Dijkstra, C. D. (2005). Cerebral perivascular macrophages and the blood brain barrier. In E. de Vries, & A. Prat (Eds.), The Blood-Brain Barrier and its Microenvironment: Basic Physiology to Neurological Disease London, UK: Informa Healthcare.




Professional Affiliations

Chair Neuroscience and Mental Health Board, Medical Research Council, UK
Editorial Boards of a number of journals
Ad hoc consultant to Biotech and Pharma

Professor V Hugh Perry
Biological Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ


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