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The University of Southampton
Biomedical Imaging Unit

Publications from the BIU

Being a core service facility, BIU staff rarely have time to undertake our own research projects.

However, we do make a significant contributions to many ongoing reasearch projects which results in co-authorship of scientific papers. We also provide, lesser advice, support and imaging services to many other projects, resulting in the BIU being acknowledged in the publications from those projects.

If you do publish work that includes data from our instruments, please do acknowledge the BIU in your paper and send us a copy for our records.

Recent Publications involving BIU staff.


Prevention of Propionibacterium acnes biofilm formation in prosthetic infections in vitro. Howlin RP, Winnard C, Angus EM, Frapwell CJ, Webb JS, Cooper JJ, Aiken SS, Bishop JY, Stoodley P. J Shoulder Elbow Surg. 2016 Dec 15. pii: S1058-2746(16)30483-9. doi: 10.1016/j.jse.2016.09.042. [Epub ahead of print] PMID: 27989720

Quantitative Assessment of Cerebral Basement Membranes Using Electron Microscopy. Sharp MM, Page A, Morris A, Weller RO, Carare RO. Methods Mol Biol. 2017;1559:367-375. doi: 10.1007/978-1-4939-6786-5_25. PMID: 28063057

The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2). Taylor-Walker G, Lynn SA, Keeling E, Munday R, Johnston DA, Page A, Scott JA, Goverdhan S, Lotery AJ, Ratnayaka JA. Exp Eye Res. 2016 Dec;153:110-121. doi: 10.1016/j.exer.2016.10.013. PMID: 27751744

High-Velocity Microsprays Enhance Antimicrobial Activity in Streptococcus mutans Biofilms. Fabbri S, Johnston DA, Rmaile A, Gottenbos B, De Jager M, Aspiras M, Starke EM, Ward MT, Stoodley P. J Dent Res. 2016 Dec;95(13):1494-1500. PMID: 27554642

Development of X-ray micro-focus computed tomography to image and quantify biofilms in central venous catheter models in vitro. Niehaus WL, Howlin RP, Johnston DA, Bull DJ, Jones GL, Calton E, Mavrogordato MN, Clarke SC, Thurner PJ, Faust SN, Stoodley P. Microbiology. 2016 Sep;162(9):1629-1640. doi: 10.1099/mic.0.000334. PMID: 27384949

Streptococcus mutans biofilm transient viscoelastic fluid behaviour during high-velocity microsprays. Fabbri S, Johnston DA, Rmaile A, Gottenbos B, De Jager M, Aspiras M, Starke EM, Ward MT, Stoodley P. J Mech Behav Biomed Mater. 2016 Jun;59:197-206. doi: 10.1016/j.jmbbm.2015.12.012. PMID: 26771168

High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: insights on bone development, ageing, health and disease. Goggin PM, Zygalakis KC, Oreffo RO, Schneider P. Eur Cell Mater. 2016 May 22;31:264-95. PMID: 27209400

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy. Keable A, Fenna K, Yuen HM, Johnston DA, Smyth NR, Smith C, Al-Shahi Salman R, Samarasekera N, Nicoll JA, Attems J, Kalaria RN, Weller RO, Carare RO. Biochim Biophys Acta. 2016 May;1862(5):1037-46. doi: 10.1016/j.bbadis.2015.08.024. PMID: 26327684

Accuracy of diagnostic testing in primary ciliary dyskinesia. Jackson CL, Behan L, Collins SA, Goggin PM, Adam EC, Coles JL, Evans HJ, Harris A, Lackie P, Packham S, Page A, Thompson J, Walker WT, Kuehni C, Lucas JS. Eur Respir J. 2016 Mar;47(3):837-48. doi: 10.1183/13993003.00749-2015. PMID: 26647444

Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation. Stead R, Musa MG, Bryant CL, Lanham SA, Johnston DA, Reynolds R, Torrens C, Fraser PA, Clough GF. J Hypertens. 2016 Mar;34(3):452-63; discussion 463. doi: 10.1097/HJH.0000000000000833. PMID: 26682783

Diagnostic Methods in Primary Ciliary Dyskinesia. Lucas JS, Paff T, Goggin P, Haarman E. Paediatr Respir Rev. 2016 Mar;18:8-17. doi: 10.1016/j.prrv.2015.07.017. Review. PMID: 26362507


Further karyosystematic studies of the Boreonectesgriseostriatus (De Geer) group of sibling species (Coleoptera, Dytiscidae)-characterisation of B.emmerichi (Falkenström, 1936) and additional European data. Angus RB, Angus EM, Jia F, Chen ZN, Zhang Y. Comp Cytogenet. 2015 Mar 31;9(1):133-44. doi: 10.3897/CompCytogen.v9i1.4463. PMID: 25893080

Intracellular residency of Staphylococcus aureus within mast cells in nasal polyps: A novel observation. Hayes SM, Howlin R, Johnston DA, Webb JS, Clarke SC, Stoodley P, Harries PG, Wilson SJ, Pender SL, Faust SN, Hall-Stoodley L, Salib RJ. J Allergy Clin Immunol. 2015 Jun;135(6):1648-51. doi: 10.1016/j.jaci.2014.12.1929. PMID: 25680455

A case report of primary ciliary dyskinesia, laterality defects and developmental delay caused by the co-existence of a single gene and chromosome disorder. Casey JP, Goggin P, McDaid J, White M, Ennis S, Betts DR, Lucas JS, Elnazir B, Lynch SA. BMC Med Genet. 2015 Jun 30;16:45. doi: 10.1186/s12881-015-0192-z. PMID: 26123568

Exploring the diversity in Citrus fruit colouration to decipher the relationship between plastid ultrastructure and carotenoid composition. Lado J, Zacarías L, Gurrea A, Page A, Stead A, Rodrigo MJ. Planta. 2015 Sep;242(3):645-61. doi: 10.1007/s00425-015-2370-9. PMID: 26202736

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. Leyva-Mendivil MF, Page A, Bressloff NW, Limbert G. J Mech Behav Biomed Mater. 2015 Sep;49:197-219. doi: 10.1016/j.jmbbm.2015.05.010. PMID: 26042766

Fruit shading enhances peel color, carotenes accumulation and chromoplast differentiation in red grapefruit. Lado J, Cronje P, Alquézar B, Page A, Manzi M, Gómez-Cadenas A, Stead AD, Zacarías L, Rodrigo MJ. Physiol Plant. 2015 Aug;154(4):469-84. doi: 10.1111/ppl.12332. PMID: 25676857


A scanning electron microscope characterisation of biofilm on failed craniofacial osteosynthesis miniplates. Jhass AK, Johnston DA, Gulati A, Anand R, Stoodley P, Sharma S. J Craniomaxillofac Surg. 2014 Oct;42(7):e372-8. doi: 10.1016/j.jcms.2014.03.021. PMID: 24780352

Failure of perivascular drainage of β-amyloid in cerebral amyloid angiopathy. Hawkes CA, Jayakody N, Johnston DA, Bechmann I, Carare RO. Brain Pathol. 2014 Jul;24(4):396-403. doi: 10.1111/bpa.12159. PMID: 24946077

Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition. Sun C, Velazquez MA, Marfy-Smith S, Sheth B, Cox A, Johnston DA, Smyth N, Fleming TP. Development. 2014 Mar;141(5):1140-50. doi: 10.1242/dev.103952. PMID: 24504338

Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid. Hirst RA, Jackson CL, Coles JL, Williams G, Rutman A, Goggin PM, Adam EC, Page A, Evans HJ, Lackie PM, O'Callaghan C, Lucas JS. PLoS One. 2014 Feb 25;9(2):e89675. doi: 10.1371/journal.pone.0089675. PMID: 24586956


Exome analysis resolves differential diagnosis of familial kidney disease and uncovers a potential confounding variant. Gibson J, Gilbert RD, Bunyan DJ, Angus EM, Fowler DJ, Ennis S. Genet Res (Camb). 2013 Dec;95(6):165-73. doi: 10.1017/S0016672313000220. PMID: 24472419

Cisplatin-induced haemolytic uraemic syndrome associated with a novel intronic mutation of CD46 treated with eculizumab. Gilbert RD, Stanley LK, Fowler DJ, Angus EM, Hardy SA, Goodship TH. Clin Kidney J. 2013 Aug;6(4):421-425. PMID: 24422172

Eculizumab therapy for atypical haemolytic uraemic syndrome due to a gain-of-function mutation of complement factor B. Gilbert RD, Fowler DJ, Angus E, Hardy SA, Stanley L, Goodship TH. Pediatr Nephrol. 2013 Aug;28(8):1315-8. doi: 10.1007/s00467-013-2492-x. PMID: 23624872

Rat astrocytic tumour cells are associated with an anti-inflammatory microglial phenotype in an organotypic model. Billingham C, Powell MR, Jenner KA, Johnston DA, Gatherer M, Nicoll JA, Boche D. Neuropathol Appl Neurobiol. 2013 Apr;39(3):243-55. doi: 10.1111/j.1365-2990.2012.01283.x. PMID: 22631872


Static respiratory cilia associated with mutations in Dnahc11/DNAH11: a mouse model of PCD. Lucas JS, Adam EC, Goggin PM, Jackson CL, Powles-Glover N, Patel SH, Humphreys J, Fray MD, Falconnet E, Blouin JL, Cheeseman MT, Bartoloni L, Norris DP, Lackie PM. Hum Mutat. 2012 Mar;33(3):495-503. doi: 10.1002/humu.22001. PMID: 22102620


Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Cowan CM, Bossing T, Page A, Shepherd D, Mudher A. Acta Neuropathol. 2010 Nov;120(5):593-604. doi: 10.1007/s00401-010-0716-8. PMID: 20617325

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Beers SA, French RR, Chan HT, Lim SH, Jarrett TC, Vidal RM, Wijayaweera SS, Dixon SV, Kim H, Cox KL, Kerr JP, Johnston DA, Johnson PW, Verbeek JS, Glennie MJ, Cragg MS. Blood. 2010 Jun 24;115(25):5191-201. doi: 10.1182/blood-2010-01-263533. PMID: 20223920


Degenerating synaptic boutons in prion disease: microglia activation without synaptic stripping. Sisková Z, Page A, O'Connor V, Perry VH. Am J Pathol. 2009 Oct;175(4):1610-21. doi: 10.2353/ajpath.2009.090372. PMID: 19779137


Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JA, Perry VH, Weller RO. Neuropathol Appl Neurobiol. 2008 Apr;34(2):131-44. doi: 10.1111/j.1365-2990.2007.00926.x. PMID: 18208483


Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. Böse K, Nischt R, Page A, Bader BL, Paulsson M, Smyth N. J Biol Chem. 2006 Dec 22;281(51):39620-9. PMID: 17023412


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