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BRAIN UK

Lay Summaries of studies supported by BRAIN UK by category: Tumour

BRAIN UK is funded by Brain Tumour Research which enables us to support tumour studies.

Our tumour studies are split into 7 categories:

Please click on the links within each category study below to view the individual lay summaries.

Glioblastoma

BRAIN UK Study Ref Lay Summary Project status
14/004 Expression analysis of candidate transcripts potentially involved in human brain tumourigenesis Active
14/010 Designing a glioma panel Closed
14/012 Identifying and characterising treatment-resistant subclones in glioblastoma multiforme Active
15/001 Intratumoural Heterogeneity in GBM Active
15/005 Dissecting the origins of central nervous system tumours exhibiting neuromesodermal differentiation Closed
15/017 PPAR expression in glioblastoma as a putative prognostic biomarker Closed
17/002 Identification of novel therapeutic targets and/or predictive biomarkers in brain gliomas Closed
17/004 Single-cell phenotyping technique applied to glioblastoma tumour samples as compared to normal brain tissue. Closed
17/005 Characterization and analysis of the brain tumour perivascular niche Active
17/013 Establishing microglial phenotype in glioblastoma as a potential target for therapeutic intervention. Active
18/003 Validation of prognostic markers and therapeutic targets in a large cohort of primary versus recurrent glioblastomas Closed
18/008 Characterising the role of chromatin regulator EZH2 in glioblastoma Closed
18/009 Dissecting GBM invasion Closed
18/013 Proteomic analysis of primary and recurrent glioblastoma – a pilot study Closed
19/005 Spatial subtyping of glioblastoma using in situ sequencing (ISS) Active
19/009 Characterisation of the Glioblastoma Immune Microenvironment Active
20/009 Mechanistic insight into the regulation of mRNA decay and translational repression by microRNAs and their implication in glioblastoma tumourigenesis Active
20/012 Novel markers of seizure susceptibility in Glioblastoma progression Active
20/013 Quantitative Ultrasound Differentiates High Grade Glioma and Healthy Brain Tissue ex vivo Closed
21/004 Spatial transcriptomic analysis of glioblastoma for assessing extrachromosomal DNA impact Active
21/014 Evaluation of the prognostic power of protein markers of invading glioblastoma cells Active
22/001 A study of telomere biology in gliomas and drivers of genomic instability Active
22/002 ATR drives glioma cell invasion via macropinocytic integrin recycling Closed
22/014 Development of a cheap sensitive blood test for early detection of new and proven biomarkers of glioblastoma using fluorescent carbon dots and nanophotonics Active
22/017 Microglia activation in IDH1 WT glioma is essential for peripheral macrophage recruitment Active
22/021 Multi-modal computational interrogation of the molecular-morphological intersection in brain tumours Active
23/006 Ascertaining the role of SSTR2 in skull base tumours and brain cancer and potential utility as a diagnostic and/or prognostic biomarker and therapeutic target Active
23/008 Investigation of FGF receptor functions in human glioblastoma Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Other Glial Tumour

BRAIN UK Study Ref Lay Summary Project Status
13/001 Are neurodegenerative diseases and gliomas inverse comorbidities? Closed
13/002 Investigating inflammation of the normal appearing brain in patients with low-grade glioma Closed
14/004 Expression analysis of candidate transcripts potentially involved in human brain tumourigenesis Active
14/008 An analysis of PPAR expression in human gliomas: its use as a novel diagnostic, prognostic and predictive biomarker Closed
15/006 Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings Active
16/002 Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches. Closed
16/015 The development of a molecular methodology for improved detection of Isocitrate Dehydrogenase mutations in diffuse gliomas. Closed
17/002 Identification of novel therapeutic targets and/or predictive biomarkers in brain gliomas Closed
18/005 An Investigation of the Clinical Utility of Genetic and Epigenetic Profiling in Glioma Closed
19/001 Molecular analyses of glial and glioneuronal tumours by DNA methylation profiling and next generation sequencing (NGS) Active
19/010 Investigating a role for dystrophin in survival outcomes of low grade glioma patients: a pilot study Active
20/001 Relating neuropathological features to clinical outcome in spinal ependymomas Active
20/016 Bithalamic Gliomas in children and adolescents: clinical, histopathological, (epi-)genomic, molecular and survival characteristics Closed
21/002 Investigating a Surrogate Marker to Distinguish Astrocytomas and Oligodendrogliomas Active
21/007 Investigating regional heterogeneity and progression-associated markers in oligodendrogliomas Active
21/011 Immunohistochemical study of H3.3 K27M expression in canine glioma: a potential model for human diffuse midline glioma Closed
21/019 Classification and characterisation of spinal glial tumours Active
22/003 Role of microglial subtypes in neurodevelopmental brain diseases Active
22/011 Artificial intelligence-based reconstruction of the WHO 2021 diagnostic algorithm for adult-type diffuse gliomas Active
22/015 Retrospective and prospective analysis of digital images of histology slides of brain tumours using machine learning and deep learning to predict/identify molecular properties Active
22/017 Microglia activation in IDH1 WT glioma is essential for peripheral macrophage recruitment Active
22/021 Multi-modal computational interrogation of the molecular-morphological intersection in brain tumours Active
23/001 Investigating the expression of BACE1 in human astrocytoma Active
23/015 Epidemiologic, Histologic, and Molecular Features of Methylation Class Pleomorphic Xanthoastrocytoma Active
23/023 Understanding microenvironmental determinants of glioblastoma invasion Active
24/002 Characterization of rare neuronal and glial tumour types to increase diagnostic accuracy, identify treatment targets and improve prognostication Active
24/004 P16 expression as a surrogate marker for homozygous deletion of CDKN2A in IDH-mutant astrocytomas Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Meningioma

BRAIN UK Study Ref Lay Summary Project Status
14/009 The role of Numb in the stability and activity of p53 in merlin-deficient tumours schwannoma and meningioma Closed
14/015 The role of Endogenous Retroviral proteins in the development of the tumours of the nervous system and as potential immunotherapy and/or drug targets Closed
15/011 A pilot study analyzing the effect of driver mutations on the (phospho)proteome and microenvironment of meningiomas (and gliomas). Active
18/006 Study of Biological Abnormalities in Meningiomas (Lay Summary NOT AVAILABLE) Closed
23/018 A Study of Tumours and Embryology of the Meninges and Skull (STEMS) Active
23/020 Investigation the role of Cellular Prion protein (PrP C) in multi drug resistance (MDR) in schwannoma and meningioma tumours Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Metastatic Tumour

BRAIN UK Study Ref Lay Summary Project Status
15/006 Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings Active
16/001 Investigation of the role of the c-MET proto-oncogene and the PI3K/AKT/mTOR pathway in brain metastasis. Active
17/012 Defining changes in the tumour microenvironment of melanoma brain metastases following anti-PD-1 and anti-CTLA-4 antibody therapy Active
20/005 Characterisation of the epigenetic changes induced by targeted radiotherapy for brain metastases Active
21/012 Defining the role of STAT3 in astrocyte adaptation to hypoxia as therapeutic target in brain cancers Active
23/010 The role of amyloid-precursor protein processing (APP) in breast cancer; lessons learnt from Alzheimer’s disease Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Paediatric Tumour

BRAIN UK Study Ref Lay Summary Project Status
14/016 Molecular Characterisation of Childhood Craniopharyngioma and Identification and Testing of Novel Drug Targets Active
15/009 Assessment of expression and potential role of prmt5 and its upstream and downstream regulators in paediatric tumours Closed
15/015 Examining the genomic landscape of rare brain tumour types Active
16/002 Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches. Active
16/007 INSTINCT Active
16/008 Developing a Biomarker for Spinal Lipoma Closed
16/017 Molecular pathology of infant gliomas Closed
17/003 Molecular Pathology of Paediatric Gliomatosis Cerebri Closed
17/007 Research and Innovation for Paediatric Low Grade Brain Tumours-Incorporating the SIGNAL and PINNACLE multicentre studies Active
17/008 Analysis of paediatric brain tissue by RAMAN imaging technology Closed
18/001 Role of c-Myc in choroid plexus tumours Closed
19/012 Impact of EZH2-regulated H3K27 methylation on microglial pro-tumoral activation in Diffuse Intrinsic Pontine Glioma Closed
20/006 Validation of diagnostic antibody for supratentorial ependymoma on human tissue sections Active
20/008 A novel radioimmunotherapy approach for the treatment of recurrent medulloblastoma. Active
20/016 Bithalamic Gliomas in children and adolescents: clinical, histopathological, (epi-)genomic, molecular and survival characteristics Closed
21/017 Classification and characterisation of high grade gliomas in teenagers and young adults Active
22/010 3D cerebellar models to predict response to novel combination therapy for medulloblastoma with poor prognosis Active
22/013 The New Roads Team – Innovative approaches to curing Brain Tumours Active
23/005 Divergent differentiation in Brain Tumours Active
23/006 Ascertaining the role of SSTR2 in skull base tumours and brain cancer and potential utility as a diagnostic and/or prognostic biomarker and therapeutic target Active
23/019 Mass spectrometry mapping of childhood primary and recurrent cerebellar brain tumours Active
23/027 Molecular characterisation of novel and rare subtypes of high-grade glioma occurring in the paediatric and young adult age groups Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Pituitary Tumour

BRAIN UK Study Ref Lay Summary Project Status
15/016 Molecular neuropathology of posterior pituitary/TTF-1-positive neoplasms Closed
19/003 Predicting recurrence/regrowth of non-functioning pituitary adenoma by a combination of patients' clinical, biochemical, radiological and immunohistochemical outcomes. Closed
19/013 Analysis of senescence in pituitary adenomas Active
20/010 Pathological and molecular stratification of ACTH-secreting pituitary tumours to predict recurrence after bilateral adrenalectomy Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Other

BRAIN UK Study Ref Lay Summary Project Status
14/006 Large scale genetic and epigenetic screen of chordoma Active
14/016 Molecular Characterisation of Childhood Craniopharyngioma and Identification and Testing of Novel Drug Targets Active
15/012 Investigating the role of macrophages in schwannoma tumours of the PNS. Closed
16/011 Identification of novel therapeutic targets in malignant peripheral nerve sheath tumours (MPNST) Closed
16/018 Determining the cell of origin of primary central nervous system lymphomas Closed
18/004 Contribution of soft tissue tumours to DNA methylation-based sarcoma classifier Closed
18/014 Whole Exome Sequencing of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System Active
19/002 Molecular analyses of adult brain tumours by conventional molecular tests and DNA methylation profiling Active
21/008 Computational pathology to risk stratify solitary fibrous tumours: an integrated approach using digital pathology, machine learning and genetics Active
21/010 Molecular diagnostics of brain tumours with Nanopore technology Active
21/013 Histological and molecular characterisation of the hypoxic and inflammatory microenvironment at the brain tumour invasive margin Closed
22/004 Validation of Trimethyl Histone H3 (Lys27) Antibody Active
22/009 Understanding the role of the tumour microenvironment in ependymoma tumours Active
22/016 Elucidating the Tumour Microenvironment of Primary Central Nervous System Lymphoma Active
22/020 Targeting the serine synthesis pathway in central nervous system lymphoma Active
23/006 Ascertaining the role of SSTR2 in skull base tumours and brain cancer and potential utility as a diagnostic and/or prognostic biomarker and therapeutic target Active
23/016 Verifying the surrogate marker, NCOA2, for identifying the HEY1-NCOA2 fusion gene in mesenchymal chondrosarcoma (MCS) Active
23/025 Development of a mass-spectrometry tissue classifier for rapid diagnosis of brain tumours Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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