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The University of Southampton
BRAIN UK

Lay Summaries of studies supported by BRAIN UK by category: Tumour

BRAIN UK is partly funded by Brain Tumour Research Charity which enables us to support tumour studies. 

 Our tumour studies are split into 7 categories:

Please click on the links within each category study below to view the individual lay summaries.

Glioblastoma  

BRAIN UK Study Ref Lay Summary Project status
14/004 Expression analysis of candidate transcripts potentially involved in human brain tumourigenesis Active
14/010 Designing a glioma panel Closed
14/012 Identifying and characterising treatment-resistant subclones in glioblastoma multiforme Active
15/001 Intratumoural Heterogeneity in GBM Active
15/005 Dissecting the origins of central nervous system tumours exhibiting neuromesodermal differentiation Closed
15/017 PPAR expression in glioblastoma as a putative prognostic biomarker Closed
17/002 Identification of novel therapeutic targets and/or predictive biomarkers in brain gliomas Active
17/004 Single-cell phenotyping technique applied to glioblastoma tumour samples as compared to normal brain tissue. Closed
17/005 Characterization and analysis of the brain tumour perivascular niche Active
17/013 Establishing microglial phenotype in glioblastoma as a potential target for therapeutic intervention. Active
18/003 Validation of prognostic markers and therapeutic targets in a large cohort of primary versus recurrent glioblastomas Active
18/008 Characterising the role of chromatin regulator EZH2 in glioblastoma Closed
18/009 Dissecting GBM invasion Active
18/013 Proteomic analysis of primary and recurrent glioblastoma – a pilot study Closed
19/005 Spatial subtyping of glioblastoma using in situ sequencing (ISS) Active
19/009 Characterisation of the Glioblastoma Immune Microenvironment Active
20/009 Mechanistic insight into the regulation of mRNA decay and translational repression by microRNAs and their implication in glioblastoma tumourigenesis Active
20/012 Novel markers of seizure susceptibility in Glioblastoma progression Active
20/013 Quantitative Ultrasound Differentiates High Grade Glioma and Healthy Brain Tissue ex vivo Active
21/004 Spatial transcriptomic analysis of glioblastoma for assessing extrachromosomal DNA impact Active
21/014 Evaluation of the prognostic power of protein markers of invading glioblastoma cells Active

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Other Glial Tumour 

BRAIN UK Study Ref   Lay Summary Project Status  
13/001 Are neurodegenerative diseases and gliomas inverse comorbidities? Closed
13/002 Investigating inflammation of the normal appearing brain in patients with low-grade glioma Closed
14/004 Expression analysis of candidate transcripts potentially involved in human brain tumourigenesis Active
14/008 An analysis of PPAR expression in human gliomas: its use as a novel diagnostic, prognostic and predictive biomarker Closed
15/006 Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings Active
16/002 Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches. Active
16/015 The development of a molecular methodology for improved detection of Isocitrate Dehydrogenase mutations in diffuse gliomas. Closed
17/002 Identification of novel therapeutic targets and/or predictive biomarkers in brain gliomas Active
18/005 An Investigation of the Clinical Utility of Genetic and Epigenetic Profiling in Glioma Closed
19/001 Molecular analyses of glial and glioneuronal tumours by DNA methylation profiling and next generation sequencing (NGS) Active
19/010 Investigating a role for dystrophin in survival outcomes of low grade glioma patients: a pilot study Active
20/001 Relating neuropathological features to clinical outcome in spinal ependymomas Active
20/016  Bithalamic Gliomas in children and adolescents: clinical, histopathological, (epi-)genomic, molecular and survival characteristics Active
21/002 Investigating a Surrogate Marker to Distinguish Astrocytomas and Oligodendrogliomas Active
21/007 Investigating regional heterogeneity and progression-associated markers in oligodendrogliomas Active
21/011 Immunohistochemical study of H3.3 K27M expression in canine glioma: a potential model for human diffuse midline glioma Active

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Meningioma 

BRAIN UK Study Ref Lay Summary Project Status   
14/009 The role of Numb in the stability and activity of p53 in merlin-deficient tumours schwannoma and meningioma Closed
14/015 The role of Endogenous Retroviral proteins in the development of the tumours of the nervous system and as potential immunotherapy and/or drug targets Active
15/011 Study analyzing the effect of driver mutations on the (phospho)proteome and microenvironment of meningiomas (and gliomas) Active
18/006 Study of Biological Abnormalities in Meningiomas (Lay Summary NOT AVAILABLE) Closed

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Metastatic Tumour 

BRAIN UK Study Ref   Lay Summary   Project Status
15/006 Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings Active
16/001 Investigation of the role of the c-MET proto-oncogene and the PI3K/AKT/mTOR pathway in brain metastasis. Active
17/012 Defining changes in the tumour microenvironment of melanoma brain metastases following anti-PD-1 and anti-CTLA-4 antibody therapy Active
20/005 Characterisation of the epigenetic changes induced by targeted radiotherapy for brain metastases Active

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Paediatric Tumour  

BRAIN UK Study Ref  Lay Summary Project Status 
14/016 Molecular Characterisation of Childhood Craniopharyngioma and Identification and Testing of Novel Drug Targets Active
15/009 Assessment of expression and potential role of prmt5 and its upstream and downstream regulators in paediatric tumours Closed
15/015 Examining the genomic landscape of rare brain tumour types Active
16/002 Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches. Active
16/007 INSTINCT Active
16/008 Developing a Biomarker for Spinal Lipoma Active
16/017 Molecular pathology of infant gliomas Closed
17/003 Molecular Pathology of Paediatric Gliomatosis Cerebri Closed
17/007 Research and Innovation for Paediatric Low Grade Brain Tumours-Incorporating the SIGNAL and PINNACLE multicentre studies Active
17/008 Analysis of paediatric brain tissue by RAMAN imaging technology Closed
18/001 Role of c-Myc in choroid plexus tumours Closed
19/012 Impact of EZH2-regulated H3K27 methylation on microglial pro-tumoral activation in Diffuse Intrinsic Pontine Glioma Active
20/006 Validation of diagnostic antibody for supratentorial ependymoma on human tissue sections Active
20/008 A novel radioimmunotherapy approach for the treatment of recurrent medulloblastoma. Active
20/016 Bithalamic Gliomas in children and adolescents: clinical, histopathological, (epi-)genomic, molecular and survival characteristics Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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Pituitary Tumour 

BRAIN UK Study Ref   Lay Summary   Project Status
15/016 Molecular neuropathology of posterior pituitary/TTF-1-positive neoplasms Active
19/003 Predicting recurrence/regrowth of non-functioning pituitary adenoma by a combination of patients' clinical, biochemical, radiological and immunohistochemical outcomes. Active
19/013 Analysis of senescence in pituitary adenomas Active
20/010 Pathological and molecular stratification of ACTH-secreting pituitary tumours to predict recurrence after bilateral adrenalectomy Active

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Other 

BRAIN UK Study Ref     Lay SummaryProject Status
14/006 Large scale genetic and epigenetic screen of chordoma Active
14/016 Molecular Characterisation of Childhood Craniopharyngioma and Identification and Testing of Novel Drug Targets Active
15/012 Investigating the role of macrophages in schwannoma tumours of the PNS. Closed
16/011 Identification of novel therapeutic targets in malignant peripheral nerve sheath tumours (MPNST) Closed
16/018 Determining the cell of origin of primary central nervous system lymphomas Closed
18/004 Contribution of soft tissue tumours to DNA methylation-based sarcoma classifier Closed
18/014 Whole Exome Sequencing of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System Active
19/002 Molecular analyses of adult brain tumours by conventional molecular tests and DNA methylation profiling   Active
21/008 Computational pathology to risk stratify solitary fibrous tumours: an integrated approach using digital pathology, machine learning and genetics Active
21/010 Molecular diagnostics of brain tumours with Nanopore technology Active
21/013 Histological and molecular characterisation of the hypoxic and inflammatory microenvironment at the brain tumour invasive margin Active

If you are working in a similar area and would like your details passed to the Principal Investigator of the study with a view to potential collaboration then please click on the 'suggest collaboration' button below.

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