This section contains all of the research publications generated by projects supported by BRAIN UK. The publications have been split into tumour and non-tumour. Please see below for the most recent 2023 and 2022 publications.
Download the full list of publications from the previous years here.
Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients. Harland AJ, Perks CM, White P, Kurian KM, Barber HR. Cancer Med. 2023 Jul;12(13):14426-14439. doi: 10.1002/cam4.6071. Epub 2023 May 22. PMID: 37212470; PMCID: PMC10358216
Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization study. Howell AE, Relton C, Martin RM, Zheng J, Kurian KM. Sci Rep. 2023 Apr 21;13(1):6590. doi: 10.1038/s41598-023-33621-1. PMID: 37085538; PMCID: PMC10121678.
Pre-diagnostic blood biomarkers for adult glioma. Andrews LJ, Davies P, Herbert C, Kurian KM. Front Oncol. 2023 May 17;13:1163289. doi: 10.3389/fonc.2023.1163289. PMID: 37265788; PMCID: PMC10229864.
Refining the Intraoperative Identification of Suspected High-Grade Glioma Using a Surgical Fluorescence Biomarker: GALA BIDD Study Report. Watts C, Dayimu A, Matys T, Ashkan K, Price S, Jenkinson MD, Doughton G, Mather C, Young G, Qian W, Kurian KM. J Pers Med. 2023 Mar 13;13(3):514. doi: 10.3390/jpm13030514. PMID: 36983696; PMCID: PMC10058333.
DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification. Stone TJ, Mankad K, Tan AP, Jan W, Pickles JC, Gogou M, Chalker J, Slodkowska I, Pang E, Kristiansen M, Madhan GK, Forrest L, Hughes D, Koutroumanidou E, Mistry T, Ogunbiyi O, Ahmed SW, Cross JH, Hubank M, Hargrave D, Jacques TS. Neuropathol Appl Neurobiol. 2023 Apr;49(2):e12894. doi: 10.1111/nan.12894. PMID: 36843390.
Clinical impact of anti-inflammatory microglia and macrophage phenotypes at glioblastoma margins. Noorani I, Sidlauskas K, Pellow S, Savage R, Norman JL, Chatelet DS, Fabian M, Grundy P, Ching J, Nicoll JAR, Boche D. Brain Commun. 2023 Jun 2;5(3):fcad176. doi: 10.1093/braincomms/fcad176. PMID: 37324244; PMCID: PMC10265726.
Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, Sahm F, Boutros PC, Aldape K; International Consortium on Meningiomas (ICOM); Nassiri F, Zadeh G. Acta Neuropathol. 2023 Jul;146(1):145-162. doi: 10.1007/s00401-023-02571-3. Epub 2023 Apr 24. Erratum in: Acta Neuropathol. 2023 May 12;: PMID: 37093270; PMCID: PMC10261216.
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions. Bogumil H, Sill M, Schrimpf D, Ismer B, Blume C, Rahmanzade R, Hinz F, Cherkezov A, Banan R, Friedel D, Reuss DE, Selt F, Ecker J, Milde T, Pajtler KW, Schittenhelm J, Hench J, Frank S, Boldt HB, Kristensen BW, Scheie D, Melchior LC, Olesen V, Sehested A, Boué DR, Abdullaev Z, Satgunaseelan L, Kurth I, Seidlitz A, White CL, Ng HK, Shi ZF, Haberler C, Deckert M, Timmer M, Goldbrunner R, Tauziède-Espariat A, Varlet P, Brandner S, Alexandrescu S, Snuderl M, Aldape K, Korshunov A, Witt O, Herold-Mende C, Unterberg A, Wick W, Pfister SM, von Deimling A, Jones DTW, Sahm F, Sievers P. Acta Neuropathol. 2023 May;145(5):667-680. doi: 10.1007/s00401-023-02558-0. Epub 2023 Mar 18. PMID: 36933012; PMCID: PMC10119244.
Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline. Sahm F, Brandner S, Bertero L, Capper D, French PJ, Figarella-Branger D, Giangaspero F, Haberler C, Hegi ME, Kristensen BW, Kurian KM, Preusser M, Tops BBJ, van den Bent M, Wick W, Reifenberger G, Wesseling P. Neuro Oncol. 2023 Oct 3;25(10):1731-1749. doi: 10.1093/neuonc/noad100. PMID: 37279174; PMCID: PMC10547522.
Direct image to subtype prediction for brain tumors using deep learning. Hewitt KJ, Löffler CML, Muti HS, Berghoff AS, Eisenlöffel C, van Treeck M, Carrero ZI, El Nahhas OSM, Veldhuizen GP, Weil S, Saldanha OL, Bejan L, Millner TO, Brandner S, Brückmann S, Kather JN. Neurooncol Adv. 2023 Nov 1;5(1):vdad139. doi: 10.1093/noajnl/vdad139. PMID: 38106649; PMCID: PMC10724115.
Multicolor Photoluminescent Carbon Dots à La Carte for Biomedical Applications. Garcia-Millan T, Ramos-Soriano J, Ghirardello M, Liu X, Santi CM, Eloi JC, Pridmore N, Harniman RL, Morgan DJ, Hughes S, Davis SA, Oliver TAA, Kurian KM, Galan MC. ACS Appl Mater Interfaces. 2023 Sep 27;15(38):44711-44721. doi: 10.1021/acsami.3c08200. Epub 2023 Sep 16. PMID: 37715711; PMCID: PMC10540137.
Histological examination of choroid plexus epithelia changes in schizophrenia. Williams MR, Macdonald CM, Turkheimer FE. Brain Behav Immun. 2023 Jul;111:292-297. doi: 10.1016/j.bbi.2023.04.016. Epub 2023 May 5. PMID: 37150267.
Microglial inflammasome activation drives developmental white matter injury. Holloway RK, Ireland G, Sullivan G, Becher JC, Smith C, Boardman JP, Gressens P, Miron VE. Glia. 2021 May;69(5):1268-1280. doi: 10.1002/glia.23963. Epub 2021 Jan 8. PMID: 33417729; PMCID: PMC8607465.
Localized microglia dysregulation impairs central nervous system myelination in development. Holloway RK, Zhang L, Molina-Gonzalez I, Ton K, Nicoll JAR, Boardman JP, Liang Y, Williams A, Miron VE. Acta Neuropathol Commun. 2023 Mar 22;11(1):49. doi: 10.1186/s40478-023-01543-8. PMID: 36949514; PMCID: PMC10035254.
The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM. Lancet Neurol. 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910; PMCID: PMC9389452.
Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon. Banerjee G, Samra K, Adams ME, Jaunmuktane Z, Parry-Jones AR, Grieve J, Toma AK, Farmer SF, Sylvester R, Houlden H, Rudge P, Mead S, Brandner S, Schott JM, Collinge J, Werring DJ. J Neurol Neurosurg Psychiatry. 2022 May 16:jnnp-2022-328792. doi: 10.1136/jnnp-2022-328792. Epub ahead of print. PMID: 35577510.
Microglial contribution to the pathology of neurodevelopmental disorders in humans. Matuleviciute R, Akinluyi ET, Muntslag TAO, Dewing JM, Long KR, Vernon AC, Tremblay ME, Menassa DA. Acta Neuropathol. 2023 Sep 1. doi: 10.1007/s00401-023-02629-2. Epub ahead of print. PMID: 37656188.
Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion. Cortese A, Tozza S, Yau WY, Rossi S, Beecroft SJ, Jaunmuktane Z, Dyer Z, Ravenscroft G, Lamont PJ, Mossman S, Chancellor A, Maisonobe T, Pereon Y, Cauquil C, Colnaghi S, Mallucci G, Curro R, Tomaselli PJ, Thomas-Black G, Sullivan R, Efthymiou S, Rossor AM, Laurá M, Pipis M, Horga A, Polke J, Kaski D, Horvath R, Chinnery PF, Marques W, Tassorelli C, Devigili G, Leonardis L, Wood NW, Bronstein A, Giunti P, Züchner S, Stojkovic T, Laing N, Roxburgh RH, Houlden H, Reilly MM. Brain. 2020 Feb 1;143(2):480-490. doi: 10.1093/brain/awz418. PMID: 32040566; PMCID: PMC7009469.
Increased uptake of the P2X7 receptor radiotracer 18 F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice. Morgan J, Moreno O, Alves M, Baz Z, Menéndez Méndez A, Leister H, Melia C, Smith J, Visekruna A, Nicke A, Bhattacharya A, Ceusters M, Henshall DC, Gómez-Vallejo V, Llop J, Engel T. Epilepsia. 2023 Feb;64(2):511-523. doi: 10.1111/epi.17484. Epub 2022 Dec 27. PMID: 36507708; PMCID: PMC10108015.
miR-497 and 219 in blood aid meningioma classification. Abdelrahman A, Negroni C, Sahm F, Adams CL, Urbanic-Purkart T, Khalil M, Vergura R, Morelli C, Hanemann CO. J Neurooncol. 2022 Sep 8. doi: 10.1007/s11060-022-04126-0. Epub ahead of print. PMID: 36076132.
Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification. Keck MK, Sill M, Wittmann A, Joshi P, Stichel D, Beck P, Okonechnikow K, Sievers P, Wefers AK, Roncaroli F, Avula S, McCabe MG, Hayden JT, Wesseling P, Øra I, Nistér M, Kranendonk MEG, Tops BBJ, Zapotocky M, Zamecnik J, Vasiljevic A, Fenouil T, Meyronet D, von Hoff K, Schüller U, Loiseau H, Figarella-Branger D, Kramm CM, Sturm D, Scheie D, Rauramaa T, Pesola J, Gojo J, Haberler C, Brandner S, Jacques T, Sexton Oates A, Saffery R, Koscielniak E, Baker SJ, Yip S, Snuderl M, Ud Din N, Samuel D, Schramm K, Blattner-Johnson M, Selt F, Ecker J, Milde T, von Deimling A, Korshunov A, Perry A, Pfister SM, Sahm F, Solomon DA, Jones DTW. Acta Neuropathol. 2022 Nov 27. doi: 10.1007/s00401-022-02516-2. Epub ahead of print. PMID: 36437415.
Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated. Maas SLN, Stichel D, Hielscher T, Sievers P, Berghoff AS, Schrimpf D, Sill M, Euskirchen P, Blume C, Patel A, Dogan H, Reuss D, Dohmen H, Stein M, Reinhardt A, Suwala AK, Wefers AK, Baumgarten P, Ricklefs F, Rushing EJ, Bewerunge-Hudler M, Ketter R, Schittenhelm J, Jaunmuktane Z, Leu S, Greenway FEA, Bridges LR, Jones T, Grady C, Serrano J, Golfinos J, Sen C, Mawrin C, Jungk C, Hänggi D, Westphal M, Lamszus K, Etminan N, Jungwirth G, Herold-Mende C, Unterberg A, Harter PN, Wirsching HG, Neidert MC, Ratliff M, Platten M, Snuderl M, Aldape KD, Brandner S, Hench J, Frank S, Pfister SM, Jones DTW, Reifenberger G, Acker T, Wick W, Weller M, Preusser M, von Deimling A, Sahm F; German Consortium on Aggressive Meningiomas (KAM).J Clin Oncol. 2021 Dec 1;39(34):3839-3852. doi: 10.1200/JCO.21.00784. Epub 2021 Oct 7. PMID: 34618539; PMCID: PMC8713596.
Clinical implementation of integrated molecular-morphologic risk prediction for meningioma. Hielscher T, Sill M, Sievers P, Stichel D, Brandner S, Jones DTW, von Deimling A, Sahm F, Maas SLN. Brain Pathol. 2022 Nov 14:e13132. doi: 10.1111/bpa.13132. Epub ahead of print. PMID: 36377252.
Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma. Naidoo M, Jones L, Conboy B, Hamarneh W, D'Souza D, Anthony K, Machado LR. Sci Rep. 2022 Feb 25;12(1):3200. doi: 10.1038/s41598-022-07223-2. PMID: 35217778; PMCID: PMC8881458.
Are We Looking Into an Iron Age for Subarachnoid Hemorrhage? Plesnila N. Stroke. 2022 May;53(5):1643-1644. doi: 10.1161/STROKEAHA.121.037670. Epub 2022 Feb 24. PMID: 35196872.
Innate Immune Anti-Inflammatory Response in Human Spontaneous Intracerebral Hemorrhage. Shtaya A, Bridges LR, Williams R, Trippier S, Zhang L, Pereira AC, Nicoll JAR, Boche D, Hainsworth AH. Stroke. 2021 Nov;52(11):3613-3623. doi: 10.1161/STROKEAHA.121.034673. Epub 2021 Jul 20. Erratum in: Stroke. 2022 Apr;53(4):e188. PMID: 34281379; PMCID: PMC7611898.
Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease. Kumar AA, Yeo N, Whittaker M, Attra P, Barrick TR, Bridges LR, Dickson DW, Esiri MM, Farris CW, Graham D, Lin WL, Meijles DN, Pereira AC, Perry G, Rosene DL, Shtaya AB, Van Agtmael T, Zamboni G, Hainsworth AH. Stroke. 2022 Oct 7:101161STROKEAHA122037761. doi: 10.1161/STROKEAHA.122.037761. Epub ahead of print. PMID: 36205142.
Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier. Song H, McEwan PP, Ameen-Ali KE, Tomasevich A, Kennedy-Dietrich C, Palma A, Arroyo EJ, Dolle JP, Johnson VE, Stewart W, Smith DH. Acta Neuropathol. 2022 Nov;144(5):967-985. doi: 10.1007/s00401-022-02498-1. Epub 2022 Sep 15. PMID: 36107227; PMCID: PMC9547928.
SMN-deficient cells exhibit increased ribosomal DNA damage. Karyka E, Berrueta Ramirez N, Webster CP, Marchi PM, Graves EJ, Godena VK, Marrone L, Bhargava A, Ray S, Ning K, Crane H, Hautbergue GM, El-Khamisy SF, Azzouz M. Life Sci Alliance. 2022 Apr 19;5(8):e202101145. doi: 10.26508/lsa.202101145. PMID: 35440492; PMCID: PMC9018017.
Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. Xing L, Kubik-Zahorodna A, Namba T, Pinson A, Florio M, Prochazka J, Sarov M, Sedlacek R, Huttner WB. EMBO J. 2021 Jul 1;40(13):e107093. doi: 10.15252/embj.2020107093. Epub 2021 May 3. PMID: 33938018; PMCID: PMC8246068.
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Pinson A, Xing L, Namba T, Kalebic N, Peters J, Oegema CE, Traikov S, Reppe K, Riesenberg S, Maricic T, Derihaci R, Wimberger P, Pääbo S, Huttner WB. Science. 2022 Sep 9;377(6611):eabl6422. doi: 10.1126/science.abl6422. Epub 2022 Sep 9. PMID: 36074851.
The spatiotemporal dynamics of microglia across the human lifespan. Menassa DA, Muntslag TAO, Martin-Estebané M, Barry-Carroll L, Chapman MA, Adorjan I, Tyler T, Turnbull B, Rose-Zerilli MJJ, Nicoll JAR, Krsnik Z, Kostovic I, Gomez-Nicola D. Dev Cell. 2022 Aug 9:S1534-5807(22)00546-9. doi: 10.1016/j.devcel.2022.07.015. Epub ahead of print. PMID: 35977545.
Multisystem screening reveals SARS-CoV-2 in neurons of the myenteric plexus and in megakaryocytes. Gray-Rodriguez S, Jensen MP, Otero-Jimenez M, Hanley B, Swann OC, Ward PA, Salguero FJ, Querido N, Farkas I, Velentza-Almpani E, Weir J, Barclay WS, Carroll MW, Jaunmuktane Z, Brandner S, Pohl U, Allinson K, Thom M, Troakes C, Al-Sarraj S, Sastre M, Gveric D, Gentleman S, Roufosse C, Osborn M, Alegre-Abarrategui J. J Pathol. 2022 Jun;257(2):198-217. doi: 10.1002/path.5878. Epub 2022 Mar 31. PMID: 35107828; PMCID: PMC9325073.
Histopathological correlates of haemorrhagic lesions on ex vivo magnetic resonance imaging in immunized Alzheimer's disease cases. Scherlek AA, Kozberg MG, Nicoll JAR, Perosa V, Freeze WM, van der Weerd L, Bacskai BJ, Greenberg SM, Frosch MP, Boche D, van Veluw SJ. Brain Commun. 2022 Feb 3;4(1):fcac021. doi: 10.1093/braincomms/fcac021. PMID: 35224489; PMCID: PMC8870423.