Chemistry Staff Seminar Series Seminar

Graeme Day: Global lattice energy minimisation as an aid in crystal structure determination

Global lattice energy minimisation methods have been developed for predicting molecular crystal structures. I will discuss the capabilities of these methods using examples where the computational methods have been combined with experimental data (X-ray powder diffraction, transmission electron diffraction or solid state NMR) to facilitate structure determination.

Ali Tavassoli: Synthetic biology for drug discovery: cyclic peptide inhibitors of protein-protein interactions

We detail the use of a bacterial high-throughout screening platform for the discovery of protein-protein interaction inhibitors form libraries of over a hundred million cyclic peptides.