Chemical proteomics: coupling chemistry and biology to reveal protein function and post-translational modification in living systems Seminar
- Time:
- 13:00
- Date:
- 19 March 2014
- Venue:
- Building 27, Room 2001 Chemistry Highfield Southampton SO17 1BJ
For more information regarding this seminar, please email Dr Seung Lee at S.S.Lee@soton.ac.uk .
Event details
Dr Ed Tate presents a seminar as part of the Molecular Diagnostics and Theraputics Group's Seminar Series
Dr Ed Tate - Chemical proteomics: coupling chemistry and biology to reveal protein function and post-translational modification in living systems
Dr Tate says: My group works at the interface between chemistry and the life sciences, coupling novel probes with quantitative proteomics to reveal protein function and post-translational modification (PTM) in living systems. Recent work in our labs has led to chemistry-driven discovery of enzyme function, quantitative mapping of changes in protein PTMs, system-level insights into mode of action of multi-target drugs, and validation of new targets in disease. The tools and technologies we develop are also highly portable between systems and have led to insights across a wide range of biology, including cancer and apoptosis, genetic disorders, protozoan parasites, drug-resistant bacteria, heart disease and viral infection. My talk will introduce some of these tools and highlight the power and potential scope of chemical proteomics, with an emphasis on elucidation of processes that can be targeted in disease.
Speaker information
Dr Ed Tate, Imperial College London. Dr Tate leads a group of about 40 scientists (9 postdoctoral fellows, 22 PhD students, 8 MRes students, project students) dedicated to research at the interface between chemistry, the life sciences and medicine, in the emerging field of chemical biology and chemical proteomics. The unifying theme of his work is the design and application of novel chemical approaches to understand and manipulate living systems, particularly in disease. Related to this, his group also undertakes research in medicinal chemistry and total synthesis/modification of proteins and peptides. Dr Tate has graduated 12 PhD students from his lab in the past 5 years (100% success rate).