From melting temperatures to hydrogen bonds: predicting DNA properties with mesoscopic models Seminar
- Time:
- 11:00
- Date:
- 20 June 2014
- Venue:
- Building 27, Room 2003 Chemistry Highfield University of Southampton Southampton SO17 1BJ
For more information regarding this seminar, please email Jon Essex at J.W.Essex@soton.ac.uk .
Event details
Dr Gerald Weber presents a seminar as part of the Computational Systems Chemistry Seminar series
Experimental DNA melting temperatures are largely underappreciated for their capability to provide interesting information about DNA physics. Here we review some of our recent work on DNA mesoscopic model were we show that basic properties such as flexibility profiles and hydrogen bonds can be retrieved from melting temperatures [Nature Physics, 2009]. More recently we were able to obtain AU hydrogen bonds from RNA melting temperatures which are consistent with those from NMR experiments [Nucleic Acids Research, 2013]. We will also show some recent results for GU RNA mismatches and deoxyinosine.
Speaker information
Dr Gerald Weber, Department of Physics, Federal University of Minas Gerais, Brazil. Dr Weber's research interests are biophysics of DNA and RNA and how to apply physics to bioinformatics