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The University of Southampton

Synthetic probes for the investigation and the exploitation of polyketide biosynthesis Seminar

1 December 2014
Building 27, Room 2001 Chemistry University of Southampton Southampton SO17 1BJ

For more information regarding this seminar, please email Seung Lee at .

Event details

Manuela Tosin presents a seminar as part of the joint seminar series organised by Chemical Biology, Diagnostics and Therapeutics Research Group and the Organic Chemistry: Synthesis, Catalysis and Flow Research Group.

Polyketide natural products and their derivatives constitute a major source of treatments for human, animal and plant diseases:  the complete elucidation of their biosynthetic pathways is of the highest priority, as it paves the way to improved/new therapeutics via enzyme engineering and combinatorial biochemistry (synthetic biology). Despite the enormous advances in genomics, proteomics and bioinformatics, there is still a general lack of straightforward methods that allow the sampling of polyketide biocatalysis stepwise and at a molecular level.

We have recently devised a chemical approach for the isolation and characterization of polyketide biosynthetic intermediates, which consists in the premature termination of natural product assembly by small-molecule mimics of malonate extender units.

The development and the application of synthetic tools as probes for the study of polyketide biosynthesis in vitro and in vivo, as well as for the generation of novel ‘unnatural’ polyketides,  will be presented and discussed.

If you would like to talk to Dr Tosin before or after the seminar, please email Dr Seung Lee at

Speaker information

Dr Manuela Tosin, University of Warwick. Assistant Professor of Organic Chemistry

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