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The University of Southampton

Chemical and structural insight into the O-GlcNAc modification: targeting neurodegeneration Seminar

11 February 2014
Building 27, Room 2001 Chemistry University of Southampton Southampton SO17 1BJ

For more information regarding this seminar, please email Seung Lee at .

Event details

Gideon Davies presents a seminar as part of the Organic Chemistry and Chemical Biology, Diagnostic and Therapeutics Research Groups seminar series.

Research in the Davies group focusses on the conformational analysis of enzyme action (for recent example / review see Refs 1,2), especially in the area of carbohydrate chemistry. In this seminar he will focus on the modification of intracellular proteins by serine and threonine-linked N-acetylglucosamine (the so-called "O-GlcNAc modification); one of the most exciting glycosylations of higher organisms. This process, in contrast to other N- and O-linked glycosylations, is dynamic and frequently acts reciprocally to protein phosphorylation. In the seminar Professor Davies will address the O-GlcNAc modification, from its discovery - through the physical organic and structural analysis3 of its reaction mechanism - to the development and application of mechanism-based inhibitors to probe the cellular roles of O-GlcNAc. Such compounds are showing great promise for the treatment of tauopathy-based neurodegenerative disease.4


(1) Williams et al., Angew Chemie Int Ed 2014, 53, 1087.

(2) Speciale et al., Curr Opin Struct Biol 2014, 28, 1.

(3) He et al., J Am Chem Soc 2010, 132, 1807.

(4) Yuzwa et al., Nature Chemical Biology 2008, 4, 483.

All welcome to attend

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Speaker information

Professor Gideon Davies, University of York. Department of Chemistry

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