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The University of Southampton

Structure and recognition of G-quadruplexes  Seminar

21 May 2015
Building 27, Room 2003 Chemistry University of Southampton Southampton SO17 1BJ

For more information regarding this seminar, please email Jon Watts at .

Event details

Anh Tuân Phan presents a seminar as part of the Chemical Biology Diagnostics and Therapeutics Research Group's seminar series.

G-quadruplexes formed by natural DNA and RNA sequences are attractive drug targets, while engineered G-quadruplex–forming oligonucleotides have demonstrated promising pharmaceutical values. G-quadruplex structures are highly polymorphic.

I will present G-quadruplex structures recently solved in our laboratory, including new structural motifs, quadruplex-duplex hybrids, and an unprecedented left-handed quadruplex.1 I will also present our systematic investigations on the effects of different chemical modifications on G-quadruplex structure and stability.2 It is of great importance to understand how G-quadruplexes are recognized by proteins and to be able to design molecules that specifically target such structures. I will present our recent findings in this area, suggesting a general strategy for specific G-quadruplex recognition. 


1. (a) Lim K.W. & Phan A.T. (2013) Angew. Chem. Int. Ed., 52, 8566. (b) Lim K.W. et al. (2014) J. Am. Chem. Soc., 136, 17969. (c) Chung W.J. et al. (2015) Proc. Natl. Acad. Sci. USA, 112, 2729. (d) Heddi B. et al. (2015) Unpublished.

2. (a) Lech C.J. et al. (2011) Biophys. J., 101, 1987. (b) Lech C.J. et al. (2012) Chem. Commun., 48, 11425. (c) Li Z. et al. (2014) Nucleic Acids Res., 42, 4068. (d) Cheong V.V. et al. (2015) Unpublished. 

3. (a) Phan A.T. et al. (2011) Nat. Struct. Mol. Biol., 18, 796. (b) Chung W.J. et al. (2013) J. Am. Chem. Soc., 135, 13495. (c) Chung W.J. et al. (2014) Angew. Chem. Int. Ed., 53, 999. (d) Heddi B. el al. (2015) Unpublished.

Speaker information

Anh Tuân Phan, Nanyang Technological University, Singapore. School of Physical and Mathematical Sciences

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