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The University of Southampton

Exploiting conformational change: from molecular balances to transmembrane machines Seminar

29 July 2016
Building 27, Room 2003, Chemistry University of Southampton SO17 1BJ

For more information regarding this seminar, please email Steve Goldup at .

Event details

Scott Cockroft will be giving a lecture on the 29th of July covering a range of physical organic and supramolecular topics. If anyone would like to meet with Scott during his visit please contact Steve Goldup.

Conformational change is a central theme within the Cockroft group. Much of the talk will illustrate how synthetic two-state folding molecules known as molecular balances can be used to quantify difficult-to-study noncovalent interactions including van der Waals dispersion forces, hydrogenbonded cooperativity, isotope effects, and solvent effects. Moving away from equilibrium systems, the final part of the talk will introduce our early investigations into the development of transmembrane molecular machines that share many characteristics with biological transmembrane pumps. I will show how a synthetic DNA co-polymer, a transmembrane protein pore and enzymes can be assembled into biosupramolecular devices that turn over a chemical fuels to drive repeated cycles of nanomechanical motion across a membrane.

Example references:

L. Yang, C. Adam, G. S. Nichol & S. L. Cockroft, Nature Chem., 2013,5(12),1006-10.

C. Adam, L. Yang & S. L. Cockroft, Angew. Chem. Int. Ed., 2015, 54(4), 1164-7.

L. Yang, J. Brazier, T. Hubbard, D. M. Rogers & S. L. Cockroft, Angew. Chem. Int. Ed., 2016, 55, 912-6.

L. Yang, C. Adam & S. L. Cockroft, J. Am. Chem. Soc., 2015, 137(32), 10084-7.

M. A. Watson, S. L. Cockroft. Angew. Chem. Int. Ed., 2016, 55(4), 1345-9.

Speaker information

Dr Scott Cockcroft, University of Edinburgh. Dr Scott Cockcroft's research interests include physical organic chemistry, molecular recognition, non-covalent interactions, supramolecular chemistry, single-molecule biophysics and molecular machines

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