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The University of Southampton

RSC – Mid Southern Counties Scientific Seminar Seminar

8 February 2017
Building 27, Room 2001, Chemistry, University of Southampton, SO17 1BJ

For more information regarding this seminar, please email Jon Kitchen at .

Event details

Prof. Veronique Gouverneur received the Tilden Prize for her interdisciplinary work in the area of organofluorine chemistry and radiochemistry, and the impact of her discoveries in medicine.

Late Stage 18F-Fluorination for PET Imaging

The success of Positron Emission Tomography (PET) and renewed interest in [18F]radiochemistry led to creative methods to incorporate 18F into molecules of increasing complexity. Despite these advances, clinically useful radio tracers lie within a narrow accessible space with [18F]fluoroalkanes and [18F]fluoroarenes at the forefront. Many potentially high value PET 18F-labeled tracers and drugs lie outside this radiochemical space, and the ability to test tracers not amenable to traditional or newly developed 18F-labeling intervention would be a major boost for PET imaging. A more diverse range of 18F-tags could immediately serve medicinal chemists by informing the selection of lead compounds much earlier in the drug discovery pipeline. This lecture will present our general approach to late stage 18F fluorination and the recent contribution we have made to this field of research with the labeling of a range of high value 18F-tags for PET.

Speaker information

Prof. Veronique Gouverneur, University of Oxford. Véronique Gouverneur secured a PhD in chemistry at the Université Catholique de Louvain (LLN, Belgium), under the supervision of Prof. L.Ghosez. In 1992, she moved to a postdoctoral position with Prof. R. Lerner at the Scripps Research Institute (California, USA). She then accepted a position of Maîre de Conférence at the University Louis Pasteur in Strasbourg (France). She worked with Dr C. Mioskowski and was Associate Member of the ISIS Institute directed by Prof. J-M. Lehn during this period. She started her independent research career as a member of the chemistry faculty at the University of Oxford in 1998. Her research aims at developing new approaches to address long-standing problems in the synthesis of fluorinated analogues of natural products, pharmaceutical drugs and molecular [18F]labelled probes for PET imaging. Since her appointment in Oxford, she holds a tutorial fellowship at Merton College Oxford where she teaches organic chemistry. She is Professor of Chemistry at the University of Oxford since 2008 and her research, published in > 160 peer-reviewed publications and presented by invitation at > 120 (inter)national conferences, was recognised by numerous awards. She was the Blaise Pascal Chair (Ecole Normale Supérieure de Paris/Commissariat d’ Energie Atomique de Saclay/Paris Sud) (2012-2014) and is currently holding a Royal Society Wolfson Research Merit Award (2013-2018), Tetrahedron Chair 2016 and RSC Tilden Prize 2016.

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