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The University of Southampton

Tailor-made Cyclodextrins for Bio-Inspired Applications Seminar

Matthieu Sollogoub
29 June 2018
Building 27, Room 2003 Chemistry University of Southampton SO17 1BJ

For more information regarding this seminar, please email Professor Steve Goldup at .

Event details

Mathieu does some exciting chemistry combining elegant carbohydrate chemistry with supramolecular chemistry, catalysis and chemical biology.

Site-selective functionalization of complex molecules, which consists in targeting only one position out of many similar ones, is a particularly demanding challenge. Concave molecules such as cyclodextrins desperately need efficient and regioselective poly hetero-functionalization methods to expand their field of applications, but this task is highly difficult because of their high symmetry. As an illustration, there are 7826 ways to arrange six functions on the primary rim of α-cyclodextrin and 117655 ways to arrange seven functions on the primary rim of b-cyclodextrin. We delineated several strategies to access polyhetero-functionalized cyclodextrins.[1] The access to such complex structures allows applications in a wide range of areas including biomimetic supramolecular assemblies[2] and catalysis[3] that will be illustrated.

[1] Angew. Chem., Int. Ed. 2008, 47, 7060; Angew. Chem., Int. Ed. 2013, 52, 639; Nature Commun. 2014, 5, 5354.
[2] Angew. Chem. Int. Ed. 2012, 51, 487; Angew. Chem. Int. Ed. 2014, 53, 7238; Angew. Chem. Int. Ed. 2018, 57, DOI: 10.1002/anie.201802550.
[3] Angew. Chem. Int. Ed. 2013, 52, 7213; Chem 2017, 3, 174; Angew. Chem. Int. Ed. 2017, 56, 10821.

Speaker information

Professor Matthieu Sollogoub, Sorbonne Université, Institut Parisien de Chimie Moléculaire, 75005 Paris, France. Matthieu Sollogoub is Professor of Molecular Chemistry at Sorbonne Université. He started his career as a “pure” carbohydrate chemist in the direct lineage of his PhD mentor Pierre Sinaÿ at Ecole Normale Supérieure, but he now shifted towards Supramolecular chemistry using cyclodextrins, probably influenced by his post-doctoral stay in Southampton with Tom Brown. The corner-stone of his research is the ability he has developed in his group to regioselectively hetero-functionalize cyclodextrins with different chemical functions. This ability now serves to synthesize ligands encapsulating metals in a well-defined asymmetric cavity allowing stereo- and regioselective catalysis. It is also applied to synthesize molecular bricks that self-assemble in a controlled and hierarchical manner to form highly ordered assemblies with biological properties.

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