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The University of Southampton

Research project: Harrowven: First Total Synthesis of 1-Desoxyhypnophilin

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Our group were the first to effect a total synthesis of (±)-1-desoxyhypnophilin, a triquinane from the East African mushroom Lentinus crinitus exhibiting useful antimicrobial activity.

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The key step showed that allylic alcohols were compatible with Grubbs’ ring closing metathesis reaction providing a simple and high yielding route to cyclopentenols and cyclopentenones.

Related research groups

Organic Chemistry: Synthesis, Catalysis and Flow
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