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The University of Southampton

Research project: Roach: Receptronics

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The goal of the Receptronics project is to develop low-cost, label-free biomolecular detectors/sentinels by integrating concepts and methods from bionanotechnology and microelectronics.

We have been expressing and purifying ligand gated ion channels such as the eukaryotic Kir-Sur complex, and bacterial MthK and MlokI, then measuring the activity of these proteins. The ion channels are transferred to bilayer membranes suspended on an chip device for electrophysiological measurements.

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The RECEPTRONICS project is funded by the European Commission within the VIth Work Program under the Nanotechnologies and Nanosciences priority.

Controlled Delivery of Calcium Gated Mthk Channels into an On-Chip Bilayer Lipid Membrane for Electrophysiology Measurements, Zagnoni, M, M. E. Sandison, R. J. Wood, P. L. Roach and H. Morgan. μTAS2006, November 5-9 2006, Tokyo.

Related research groups

Chemical Biology, Diagnostics and Therapeutics
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