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The University of Southampton
Chemistry

Research project: Frey: Ultrafast nanoscale x–ray Microscope

Currently Active: 
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We have constructed a soft x-ray microscope based on laser High Harmonic Generation of XUV at 30 nm and demonstrated ultra-high resolution imaging of biological samples including neurons.  We continue to advance the technology for imaging in the x-ray water window and towards single protein molecule imaging as a complementary technique to cryo-EM.

The project developed from initial Basic Technology programme funding.  The x-rays are produced using ultra-fast laser technology together with high harmonic generation (HHG). Currently producing > 108 photons/s of coherent x-rays around 30 nm illuminate the sample. The beam quality and stability of the XUV is critical to the successful imaging and considerable effort has been devoted to achieving a reliable high-quality source.  Starting with recording Mie type scattering and diffraction from a self-assembled layer of 200 nm latex beads, we now utilize the technique of ptychographic phase retrieval to image biological and material samples. 

Related research groups

Computational Systems Chemistry

Key Publications

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