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The University of Southampton
Clinical Neonatal and Developmental Neurosciences Group


Project 1: Neurodevelopmental trajectories and neural correlates in children with neonatal HIE – NENAH study

In this stream of work we aim to characterise cognitive and behavioural abilities that are important for school success and socio-emotional function in school aged children with neonatal HIE who underwent hypothermia treatment, and their neural correlates (using advanced MRI to characterise brain networks). In addition, we aim to characterise neurodevelopmental trajectories from birth into school age with the aim to identify early predictors of outcome.

Action Medical Research
This study is funded by Action Medical Research.

Project 2: Testing perfusion and brain connectivity MRI for investigating and evaluating severity of HIE in the neonatal brain

Here, we investigate which structural and functional brain networks are impaired in HIE in the neonatal period, and whether alterations in specific brain networks are associated with cognitive long term outcome. In this study, we also examine brain perfusion following neonatal HIE, using a new MRI perfusion sequence (pCASL). Brain perfusion measures obtained at day 5 post delivery/presumed time of insult will be correlated with neurodevelopmental outcomes at age 3 months and then 2 years to examine whether patterns of brain perfusion can add to prediction of neurodevelopmental outcome.


Southampton Hospital Charity
This study is funded by the UHS Hospital Charity.

Project 3: Clinical predictors of neurological and developmental outcomes at toddler age and school age in infants born preterm and infants with neonatal HIE

Prediction of long term neurological, cognitive and behavioural outcomes in infants and children born too early and/or with neurological problems in the perinatal period remains difficult. In this line of work, we are investigating the predictive value of clinical routine neonatal neuroimaging, neurophysiology, and routine neurological assessments in early infancy.

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