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The University of Southampton

CHEM6127 Chromatography: Theory and Application

Module Overview

Chromatography plays a key role in the modern world. It delivers practical and sustainable innovations to enable significant advancements in areas such as healthcare delivery, life sciences, environmental management, energy, food safety, and water quality. This module will explore the tenets of modern chromatography and introduce underlying theory, advanced techniques and applications.

Aims and Objectives

Module Aims


Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Determine appropriate chromatographic technique and approach for analysis
  • Comprehend the optimisation of chromatographic methods
  • Have raised awareness of chromatographic applications areas
  • Critically evaluate the quality of acquired data


1. Tenets of chromatography • Retention • Resolution • Selectivity • Efficiency 2. Types of chromatography • High performance liquid chromatography (RP & NP) • Gas chromatography • Thin Layer chromatography 3. Detectors and advanced applications • Detectors • Ion exchange chromatography • SFC • Quantitative chromatography 4. Practical techniques • Sample preparation • Column chemistries • Method development • Advantages and disadvantages

Learning and Teaching

Teaching and learning methods

Teaching Methods • Online delivery of material by Chromacademy with plenary support from course co-ordinator • Workshops involving interaction with the instrumentation in small groups • Directed reading • Bb online support Learning Methods Independent study, student motivated peer-group study, student driven tutor support.

Independent Study118
Total study time150

Resources & Reading list

Chromacademy online resources. 



MethodPercentage contribution
Coursework 30%
Written exam  (2 hours) 70%


MethodPercentage contribution
Coursework 30%
Written exam  (2 hours) 70%

Repeat Information

Repeat type: Internal & External

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