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Southampton Clinical Trials UnitNews

ATAFUTI trial publishes trial protocol in open access journal

Published: 20 April 2018
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Women with acute uncomplicated urine infection are usually treated with antibiotics. One trial has demonstrated that delayed antibiotic treatment offered without symptom relief results in a modest reduction in antibiotic use. There is some evidence that ibuprofen provides symptom relief and reduces antibiotic use. Uva-ursi, a herbal product, has a traditional use for urinary infection symptom relief. This study sets out to test: in adult women with suspected UTI who accept the delayed prescription strategy: Do NSAIDs or uva-ursi (a herbal product) provide relief from urinary symptoms and reduce antibiotic use.

The trial protocol has been published in an open access journal

Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial



Jeanne Trill,
Catherine Simpson,
Frances Webley,
Mike Radford,
Louise Stanton,
Tom Maishman,
Angeliki Galanopoulou,
Andrew Flower,
Caroline Eyles,
Merlin Willcox,
Alastair Hay,
Gareth Griffiths,
Paul Little,
George Lewith and
Michael Moore


Trials 2017 18:421

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