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The University of Southampton
Southampton Clinical Trials Unit

Completed Trials Portfolio

Anti-CD66 Logo

Anti-CD66

Using Targeted Radiotherapy delivered by a Radio-labelled Anti-CD66 Monoclonal Antibody with high dose melphalan compared to melphalan alone, prior to Autologous Stem Cell Transplantation for Multiple Myeloma.

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ATAFUTI

Alternative Treatments of Adult Female Urinary Tract Infection: a double blind, placebo controlled, factorial randomised trial of Uva ursi and open pragmatic trial of ibuprofen.

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BioStent

Biodegradable oesophageal stents plus radiotherapy in carcinoma of the oesophagus.

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BREATHE

A controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist by either instructional DVD or by face-to-face sessions in the management of asthma in adults.

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COAST

A placebo controlled study to gather initial information on whether aspirin reduces hearing loss/ototoxicity for patients receiving cisplatin chemotherapy.

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COPPI

A multicentre randomised controlled trial comparing the efficacy of a specialist and a generic parenting programme for the treatment of preschool ADHD.

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EORTC 40983

Pre and Post-operative chemotherapy with oxaliplatin 5FU/LV V surgery alone if resectable liver metastases from colorectal origin—Phase III study

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EPOC B

An exploratory study to investigate the optimal scheduling of chemotherapy in patients with operable colorectal liver metastases.

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FACS

A randomised controlled trial to assess the cost-effectiveness of intensive versus no scheduled follow-up in patients who have undergone resection for colorectal cancer with curative intent.

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Gem-TIP

Phase I/II multicentre trial of salvage chemotherapy with Gem-TIP for relapsed germ cell cancer.

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Hip 'OP

A study to assess the effect of timing of surgical intervention on the occurrence of Avascular Necrosis in children with Developmental Dysplasia of the Hip - Early Treatment versus Intentionally Delayed Treatment.

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ICE

A Phase II trial of the addition of Ipilimumab to Carboplatin and Etoposide Chemotherapy for the first line treatment of Extensive Stage Small Cell Lung Cancer

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IELSG-19

Multicenter randomised trial of chlorambucil versus chlorambucil plux rituximab versus rituximab alone in extranodal marginal zone B-Cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma).

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IELSG-26

This prospective multi-centre cohort study has been designed to investigate the diagnostic and prognostic utility of PET scan in primary mediastinal lymphoma.

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PCV 13 in ALL

Investigating the clinical use of 13-valent pneumococcal conjugate vaccine (PCV13, Prevenar-13) in childhood Acute Lymphoblastic Leukaemia.

SABRE1

SABRE1

A randomised feasibility study of brachytherapy and surgery in good risk prostate cancer.

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SAKK 08/11

A phase III trial investigating Orteronel maintenance therapy in patients with metastatic castration resistant prostate cancer and non-progressive disease after first-line docetaxel therapy.

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SCHRIFT

Short Chemo RadioImmunotherapy in Follicular Lymphoma Trial of 90Y Ibritumomab tiuxetan (Zevalin) as therapy for first and second relapse in Follicular Lymphoma.

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STOPAH

STeroids or Pentoxifylline for Alcoholic Hepatitis.

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Trans EPOC

Investigating the molecular predictors of response in metastatic colorectal cancer.

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MENOS4

A multicentre randomised controlled trial of a breast care nurse delivered cognitive behavioural therapy (CBT) intervention to reduce the impact of hot flushes in women with breast cancer.  

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WIN

WT1 Immunity via DNA fusion Gene Vaccination in Haematological Malignancies by intramuscular injection followed by intramuscular electroporation.

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