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The University of Southampton
Southampton Clinical Trials Unit

COAST Trial

Trial Name:

COAST - Cisplatin Ototoxicity attenuated by ASpirin Trial

Description:

A placebo controlled study to gather initial information on whether aspirin reduces hearing loss/ototoxicity for patients receiving cisplatin chemotherapy.

Objectives:

Primary Objective:

Secondary Objectives:

Design:

Randomised, Phase II, double-blind, placebo-controlled, two arm Trial.

Status:

Completed

Population:

39 patients over 18 years of age in each arm deemed fit for chemotherapy according to sites own local defined cancer network protocol for chemotherapy regimes.

Publications:

COAST (Cisplatin ototoxicity attenuated by aspirin trial): A phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss

Contact details:

All Trial enquiries should be addressed to ctu@soton.ac.uk

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