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The University of Southampton
Southampton Clinical Trials Unit

EPOC B Trial

Trial Name

EPOC B - An exploratory study to investigate the optimal scheduling of chemotherapy in patients with operable colorectal liver metastases.


Multicentre randomised control trial of peri-operative versus post-operative chemotherapy for patients who have colorectal cancer liver metastases. 


Primary Objective

Secondary Ojectives


Multicentre randomised control trial for patients who have colorectal cancer with resectable liver metastases. Eligible patients will be randomised to receive either 24 weeks of chemotherapy treatment post-operatively (Arm A) or 12 weeks of chemotherapy treatment pre-operatively and 12 weeks post-operatively (Arm B).




78 colorectal cancer patients with liver metastases deemed resectable in whom the oncologist feels chemotherapy would be beneficial and who are fit for combination chemotherapy.

Contact details

All Trial enquiries should be addressed to

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