Skip to main navigationSkip to main content
The University of Southampton
Southampton Clinical Trials Unit

PCV 13 in ALL Trial

Trial Name

PCV 13 in ALL Trial - Investigating the clinical use of 13-valent pneumococcal conjugate vaccine (PCV13, Prevenar-13) in childhood Acute Lymphoblastic Leukaemia 


Non-randomised, open-label study examining the efficacy of PCV13 (Prevenar-13) in children at three time points during/after Acute Lymphoblastic Leukaemia (ALL) treatment:

i) during maintenance chemotherapy, 6 months from last intensive chemotherapy (Study group 1)
ii) at the end of treatment (Study group 2)
iii) 6 months after completion of treatment (Study group 3) 


Primary Objective:

The primary objective is to establish whether immunisation with PCV13 (Prevenar-13TM) can achieve protective levels of anti-pneumococcal antibodies in children:

  1. Receiving maintenance chemotherapy for Acute Lymphoblastic Leukaemia
  2. At the end of treatment for Acute Lymphoblastic Leukaemia
  3. 6 months after completion of treatment for Acute Lymphoblastic Leukaemia

Secondary Objectives:


Multicentre non-randomised interventional treatment trial 




120 children (40 per study group) who are receiving, or who recently completed, treatment for acute lymphoblastic leukaemia. Age 2-18 years 

Contact Details

All Trial enquiries should be addressed to

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.