Trial Name
Accuracy and Cost-Effectiveness of Dynamic Contrast Enhanced Computed Tomography in the Characterisation of Solitary Pulmonary Nodules
Description
A prospective, observational study to assess the accuracy and cost effectiveness of dynamic contrast enhanced computed tomography in the characterisation of Solitary Pulmonary Nodules.
Objectives
Primary Objetives:
- To determine with high precision, the diagnostic performances of DCE-CT and 18FDG-PET/CT in the NHS for the characterisation of solitary pulmonary nodules (SPNs).
- To use decision analytic modelling to assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs.
Secondary Objectives:
- To assess, within an NHS setting, the incremental value of incorporating the CT appearances of a SPN into the interpretation of integrated PET/CT examinations.
- To assess whether combining DCE-CT with 18FDG-PET/CT is more accurate and/or cost-effective, in the characterisation of SPNs, than either test used alone or in series.
- To document the nature and incidence of incidental extra-thoracic findings on 18FDG-PET/CT and DCE-CT undertaken for the characterisation of SPNs and model their impact on cost-effectiveness.
Design
Non interventional, prospective observational study
Status
Complete
Population
Patients with a solitary dominant pulmonary nodule between 8mm and 30mm without confirmed aetiology
Publication
Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules—the SPUtNIk study
Dynamic contrast enhanced CT in nodule characterization: How we review and report
Contact Details
All Trial enquiries should be addressed to ctu@soton.ac.uk