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The University of Southampton
Southampton Clinical Trials Unit

STOPAH Trial

Trial Name

 STOPHA - STeroids or Pentoxifylline for Alcoholic Hepatitis

Description

STOPAH is a multicentre randomised double-blind factorial (2x2) trial. The planned interventions will be prednisolone (40mg) or pentoxifylline (400mg) in one of four combinations: placebo/placebo, placebo/prednisolone, pentoxifylline/placebo or pentoxifylline/prednisolone in patients with severe alcoholic hepatitis. 

Objectives

Design

The study will be performed using a multicentre, double-blind, factorial (2 x 2) design in which patients will be randomised to one of four groups:

Status

Complete

Population

1200 patients with severe alcoholic hepatitis. 

Publication

The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial

Steroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial

Prednisolone or pentoxifylline for alcoholic hepatitis

Contact Details

All Trial enquiries should be addressed to ctu@soton.ac.uk

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