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The University of Southampton
Southampton Clinical Trials Unit

Active Trials Portfolio

ACCEPT Logo

ACCEPT

A Phase Ib/II combination of acalabrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) for patient Diffuse Large B-cell Lymphoma (DLBCL)

AGILE logo

AGILE

Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment.

AlcoChange logo

AlcoChange

Real world implementation of AlcoChange: A smartphone digital therapeutic to improve outcomes from alcohol-related liver disease.

ARGO logo

ARGO

A phase II Study of Atezolizumab with Rituximab, Gemcitabine and Oxaliplatin in patients with relapsed or refractory Diffuse Large B-Cell Lymphoma who are not candidates for High Dose Therapy

AURORA Logo

AURORA

Atezolizumab in patients with urinary tract squamous cell carcinoma: a single arm, open label, multicentre, phase II clinical trial.

BL13 logo

BL13

A Randomised Phase II Trial Assessing Trimodality Therapy With or Without Adjuvant Durvalumab (MEDI4736) to Treat Patients with Muscle-Invasive Bladder Cancer.  

CaDeT Logo

CaDeT

Multicentre trial of the clinical and cost effectiveness of a novel urinary catheter design in reducing catheter-associated urinary tract infection compared with the traditional Foley design.

CONFIRM Logo

CONFIRM

Checkpoint blockade for inhibition of relapsed mesothelioma: A phase III trial to evaluate the efficacy of nivolumab in relapsed mesothelioma

CONTRACT 2 Logo

CONTRACT 2

CONservative TReatment of Appendicitis in Children – a randomised controlled Trial – CONTRACT 2

CRAIN Logo

CRAIN

A phase 1b TiTE-CRM dose escalation clinical trial of ASTX660 in combination with standard radical chemoradiotherapy in cervical cancer.

ELECTRA logo

ELECTRA

A double-blinded feasibility study of intraoperative electron beam radiotherapy in patients with locally advanced or locally recurrent rectal cancer.

Elevate logo

Elevate

Temozolomide plus nivolumab in MGMT deficient oesophagogastric cancer.

Excalibur logo

EXCALIBUR

EXCALIBUR is a Phase III feasibility trial of SFJD in addition to best current practice for the treatment of AECOPD in UK primary care.  

HARE-40 Logo

HARE-40

Therapeutic HPV vaccine trial +/- anti-CD40 in HPV-driven squamous cell carcinoma

iDx Lung Logo

iDx Lung

A prospective study investigating autoantibody, protein/nucleic acid, and transcriptomic signatures from individuals receiving lung health checks at mobile scanners in Wessex and Yorkshire

IELSG 32 Logo

IELSG 32

A randomised Phase II Trial on high-dose Methotrexate and Cytarabine, with or without Thiotepa and Rituximab followed by brain irradiation vs. high-dose chemotherapy patients with primary CNS lymphoma

IELSG 37 Logo

IELSG 37

A randomized, open-label, two-arm phase III comparative study assessing the role of mediastinal radiotherapy after Rituximab chemotherapy to patients with newly diagnosed Primary Mediastinal Large B-Cell Lymphoma

IELSG42 Logo

IELSG 42

A phase II trial assessing sequential Methotrexate-Aracytin-based and R-ICE combinations, followed by high-dose chemotherapy in patients with systemic B-cell lymphoma with central nervous system involvement

MANCAN2 Logo

MANCAN2

A virtual self-help cognitive behavioural therapy intervention to reduce the impact of hot flush and night sweat symptoms in men with prostate cancer undergoing androgen deprivation therapy.

MAPLE Logo

MaPLe

Molecular Profiling for Lymphoma

Mustang Logo

Mustang

Investigating the role of Miglustat in the management of a patient with Tangier’s Disease: a single case experiment

Neo-AEGIS Logo

Neo-AEGIS

Neoadjuvant and adjuvant chemotherapy (Investigator’s choice Modified MAGIC or FLOT regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction

NERO logo

NERO

Niraparib Efficacy in patients with unResectable MesotheliOma: A randomised phase II trial of Niraparib versus active symptom control in patients with previously treated mesothelioma

OCTOPuS Logo

OCTOPuS

Optimising Cardiac Surgery ouTcOmes in People with diabeteS – Intervention Development Study

OptiMATe logo

OptiMATe

Optimizing MATRix as remission induction in PCNSL: De-escalated induction treatment in newly diagnosed primary CNS lymphoma – a randomized phase III trial.

ORANGE II logo

Orange II Plus

An international multicentre randomised controlled trial comparing open and laparoscopic hemihepatectomy within an enhanced recovery (ERAS) programme

Pola-R-ICE logo

Pola-R-ICE

Polatuzumab vedotin plus rituximab, ifosfamide, carboplatin and etoposide (Pola-R-ICE) versus R-ICE alone in second line treatment of diffuse large B-cell lymphoma (DLBCL)

P+R-ICE logo

P+R-ICE

An open-label, multicentre, randomised phase II Pembrolizumab in combination with R-ICE chemotherapy in relapsed/refractory diffuse large B-cell lymphoma.

REMoDL-A logo

REMoDL-A

A randomised Phase II Evaluation of Molecular Guided Therapy for Diffuse Large B-Cell Lymphoma with Acalabrutinib.

REMoDL-B Logo

REMoDL-B

A Randomised Evaluation of Molecular guided therapy for Diffuse Large B-cell Lymphoma with Bortezomib

RIVA Logo

RiVa

A phase IIa study of Rituximab and Varlilumab in relapsed or refractory B-cell malignancies

SupportBack2 logo

SupportBack2

Supporting self-management of low back pain with an internet intervention in primary care: A randomised controlled trial of clinical and cost-effectiveness.

UNIVERSAL trial

UNIVERSAL

Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission - Longitudinal (UNIVERSAL) Study

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