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The University of Southampton
Southampton Clinical Trials Unit

Active Trials Portfolio

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ACCEPT

A Phase Ib/II combination of acalabrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) for patient Diffuse Large B-cell Lymphoma (DLBCL)

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ARGO

A phase II Study of Atezolizumab with Rituximab, Gemcitabine and Oxaliplatin in patients with relapsed or refractory Diffuse Large B-Cell Lymphoma who are not candidates for High Dose Therapy

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CONFIRM

Checkpoint blockade for inhibition of relapsed mesothelioma: A phase III trial to evaluate the efficacy of nivolumab in relapsed mesothelioma

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FORECAST

Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain

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HARE-40

Therapeutic HPV vaccine trial +/- anti-CD40 in HPV-driven squamous cell carcinoma

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IELSG 32

A randomised Phase II Trial on high-dose Methotrexate and Cytarabine, with or without Thiotepa and Rituximab followed by brain irradiation vs. high-dose chemotherapy patients with primary CNS lymphoma

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IELSG 37

A randomized, open-label, two-arm phase III comparative study assessing the role of mediastinal radiotherapy after Rituximab chemotherapy to patients with newly diagnosed Primary Mediastinal Large B-Cell Lymphoma

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IELSG 42

A phase II trial assessing sequential Methotrexate-Aracytin-based and R-ICE combinations, followed by high-dose chemotherapy in patients with systemic B-cell lymphoma with central nervous system involvement

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MaPLe

Molecular Profiling for Lymphoma

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Neo-AEGIS

Neoadjuvant and adjuvant chemotherapy (Investigator’s choice Modified MAGIC or FLOT regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction

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OCTOPuS

Optimising Cardiac Surgery ouTcOmes in People with diabeteS – Intervention Development Study

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Orange II Plus

An international multicentre randomised controlled trial comparing open and laparoscopic hemihepatectomy within an enhanced recovery (ERAS) programme

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ProCAID

An open label phase I/randomised, double blind phase II study in metastatic castration resistant Prostate Cancer of AZD5363 In combination with Docetaxel and prednisolone chemotherapy

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REMoDL-B

A Randomised Evaluation of Molecular guided therapy for Diffuse Large B-cell Lymphoma with Bortezomib

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RiVa

A phase IIa study of Rituximab and Varlilumab in relapsed or refractory B-cell malignancies

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SAFA

A pragmatic multicentre double-blind randomised superiority trial investigating the clinical and cost-effectiveness of spironolactone for moderate or severe persistent adult female acne

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SoMOSA

An open label, prospective, registration, multicentre study to identify biomarkers which are modulated by treatment with the anti-IgE antibody, Xolair.

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SPIRE

A phase Ib/randomised IIa open label clinical trial combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer.

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SPUtNIk

A prospective, observational study to assess the accuracy and cost effectiveness of dynamic contrast enhanced computed tomography in the characterisation of Solitary Pulmonary Nodules.

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SupportBack2

Supporting self-management of low back pain with an internet intervention in primary care: A randomised controlled trial of clinical and cost-effectiveness.

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