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The University of Southampton
Southampton Clinical Trials Unit



Molecular Profiling for Lymphoma


This study concentrates on patients having a suspected or confirmed diagnosis of diffuse large B-cell lymphoma or follicular lymphoma grade 3b who may be suitable for targeted therapy either immediately or subsequently in the course of their illness. Lymphoma samples will be taken from the lymph node or extra nodal sites at either the time of first presentation or time of recurrence. 


The objectives of this study are:

  • To aid the identification of patients with lymphoma that may be suitable for specific targeted therapies.
  • To test whether molecular characterisation of lymphoma can be carried out as a standardised, routine practice during the treatment of patients in the NHS.
  • To capture routine clinical data to form a cohort dataset of gene changes, treatments and outcomes.
  • To relate the changes found in lymphoma biopsy samples to those seen in cfDNA in the blood.

Study Design

This is a multicentre prospective observational cohort study for the collection of tumour samples and matched blood samples from patients with suspected or confirmed diffuse large B-cell lymphoma or grade 3b follicular lymphoma.  

Study Status

Open to recruitment


3000 patients with DLBCL or grade 3b follicular lymphoma. Patients can be recruited at initial diagnosis or at the time of relapse or disease progression. 

Study Team:

Senior Trial Manager:

Josh Caddy (023 8120 5537)

Trial Manager:

Nicole Keyworth (023 8120 3785)

Clinical Data Coordinator:

Peter Navin (023 8120 5321)

Contact information


Fax: 0844 7740 621


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