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Phone:: (023) 8059 3827
Email:: T.W.Smith@soton.ac.uk

Dr. Thomas W. Smith MChem

Research Fellow in Biomethanisation of CO2

Thomas William Smith is a visiting Senior Research Assistant in Biomethanisation within Engineering and Physical Sciences at the University of Southampton.

Thomas graduated from the University of Sheffield with a MChem degree in Chemistry in 2013 before undertaking a PhD at the same institution. His PhD research focused on the development and application of novel spectroscopic tools for online headspace analysis of gases generated and consumed by pure microbial cultures and the behaviour of stable gaseous donor molecules with applications in medicine, particularly carbon monoxide releasing molecules (CORMs). Thomas joined the University of Southampton in 2017 as a Senior Research Assistant and is currently working on the optimisation and analysis of both in situ and ex situ biomethanisation as part of the IB Catalyst project “Biomethanisation of CO2 in Anaerobic Digestion Plants”.

Research

Publications

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Research interests

Thomas’s current research interests lie in gas analysis, particularly in relation to biohydrogen and biomethane production. His previous research has involved the use of online Raman spectroscopy to monitor H2 metabolism of pure cultures, the use of online infrared spectroscopy to monitor anaerobic nitric oxide metabolism in Escherichia coli and the development of in situ stable isotopic labelling methods to probe biochemical pathways relevant to gas metabolism.

Research projects

IB Catalyst Biomethanisation of CO2 in Anaerobic Digestion Plants (IB Cat H2AD)

Research group

Water and Environmental Engineering Group

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Articles

Metcalfe, G., Alahmari, S., Smith, T. W., & Hippler, M. F. A. (2019). Cavity-enhanced Raman and Helmholtz resonator photoacoustic spectroscopy to monitor the mixed sugar metabolism of E. coli. Analytical Chemistry, 91(20), 13096-13104. https://doi.org/10.1021/acs.analchem.9b03284
Southam, H. M., Smith, T. W., Lyon, R. L., Liao, C., Trevitt, C. R., Middlemiss, L. A., Cox, F. L., Chapman, J. A., El-Khamisy, S. F., Hippler, M., Williamson, M. P., Henderson, P. J. F., & Poole, R. K. (2018). A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. Redox Biology, 18, 114-123. https://doi.org/10.1016/j.redox.2018.06.008
Smith, T. W., & Hippler, M. (2017). Cavity-enhanced Raman spectroscopy in the biosciences: In situ, multicomponent, and isotope selective gas measurements to study hydrogen production and consumption by Escherichia coli. Analytical Chemistry, 89(3), 2147-2154. https://doi.org/10.1021/acs.analchem.6b04924
Tinajero-Trejo, M., Rana, N., Nagel, C., Jesse, H. E., Smith, T. W., Wareham, L. K., Hippler, M., Schatzschneider, U., & Poole, R. K. (2016). Antimicrobial activity of the manganese photoactivated carbon monoxide-releasing molecule [Mn(CO) ₃ (tpa-κ ³ N )] ⁺ against a pathogenic Escherichia coli that causes urinary infections. Antioxidants & Redox Signaling, 24(14), 765-780. https://doi.org/10.1089/ars.2015.6484

Dr. Thomas W. Smith
Room 2032 Building 25
Highfield Campus
University of Southampton
Southampton
SO17 1BJ

Room Number: 25/2032

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