Skip to main navigationSkip to main content
The University of Southampton
Wessex Imprinting GroupInformation for patients

Maternal UPD14 or Temple Syndrome

Maternal UPD14 or Temple Syndrome, is characterised by:


Genetic Causes

There is good evidence that Temple syndrome is due to a change in the expression (activation) of genes at one specific location (locus) on chromosome 14.

Temple syndrome can be caused by a person having both copies of chromosome 14 from the mother (maternal UPD of chromosome 14) or an isolated methylation (silencing mechanism) deficit at chromosome 14.

References for Maternal and Paternal uniparental disomy of chromosome 14

Privacy Settings