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Research project: Antibiotic treatment for intermittent bladder catheterisation: A randomised controlled trial of once daily prophylaxis (AnTIC)

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This randomised controlled trial is designed to find out whether people who suffer repeated urinary tract infections (UTI) related to the need to empty their bladders intermittently with a fine plastic tube (catheter); a process called clean intermittent self-catheterisation (CISC), benefit from taking continuous daily low-dose antibiotics (antibiotic prophylaxis).

Participants will have one of the two alternative treatments randomly chosen for them by computer and take part with the intention to continue with the chosen treatment for 12 months. Participants who are given prophylaxis will be able to swap between three antibiotics during the 12 months. We will then measure the number of urinary infections suffered by participants in each group and compare the results statistically to see if UTIs are less frequent amongst people taking antibiotic prophylaxis, and if so, whether the benefit is sufficiently noticeable to be important and useful to patients and the NHS.

Patients – find out how you can take part

If you would be interested in taking part in the study please:

  • contact
  • or phone 0191 208 7258
  • Or click here



The study is funded by NIHR HTA Programme and the Chief Investigator is Robert Pickard of the University of Newcastle in collaboration with Newcastle upon Tyne Hospitals NHS Foundation Trust and the University of Southampton.

Related research groups

Health Work and Systems
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