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The University of Southampton
The Immune Defence Study

Information for Participants

Immune Defence
Immune Defence

This page is to provide information to participants who have been invited to take part in the Immune Defence study by their GP practice.  At the moment, the only way to take part is by invitation from your GP practice.  The study may open to wider recruitment in the future so please check back here at a later date or follow us on Twitter @IDstudy.

The Immune Defence Study
The Immune Defence study has been designed to see if nasal sprays and websites to help you be more active/reduce stress can help people get fewer and less severe infections. This also includes COVID-19. Although it can cause more serious problems, we catch COVID-19 in a very similar way to coughs, colds and other infections.

If you take part in the study, you will be put in to one of the following groups by chance.  Putting people into groups by chance will make sure that the groups are the same to start with and allow a fair comparison between the groups:

·       gel-based nasal spray;

·       liquid-based nasal spray;

·       website to help you get more active/reduce stress;

·       usual care for infections. 

In all groups you will carry on receiving usual NHS care.

The study will last for 12 months and each month you will be asked to complete some questions about any infections you have had and about your general health.

If you sign up you will be issued with a patient identification number (PID). Your PID number is made up of numbers and letters in this format for example:-X011-X0001 Please note that the first character of each set is a letter, and all subsequent characters are numbers.

Participant information sheet
Please find below the participant information sheet, which provides full details of the Immune Defence Study and has been designed for people who have been invited to take part in the study by their GP practice.

Participant consent form.
If you have been invited to take part in the study by your GP practice, you will be asked to complete a consent form online to show that you agree to take part.  Please find an example of the consent from below.  This is for information only.  To sign up you will need to be invited by your doctor’s surgery and then visit the Immune Defence study website ( You will need your participant code which will be on the letter from your GP practice.

If you have any questions about the study, please email the Immune Defence Study team on .


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