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The University of Southampton
Institute for Life Sciences

Patricia Goggin IfLS PhD: Correlative light, X-ray, and electron microscopy framework for 3D bone imaging at the cell level across the lifecourse, 2020

Postgraduate Research Student

Patricia Goggin's Photo

Hi, I'm Patricia Goggin and I studied IfLS PhD: Correlative light, X-ray, and electron microscopy framework for 3D bone imaging at the cell level across the lifecourse within Institute for Life Sciences at the University of Southampton.

It is exciting and challenging to be approaching a medical problem using the tools of the engineer and mathematician. The multidisciplinary approach has the potential to produce novel insights in cell biology.

I studied Chemistry and Medical Science at Queen’s University Belfast, and have worked as an electron microscopist for nearly 20 years. Since 2006 I have been employed at the Biomedical Imaging Unit in Southampton General Hospital. I use electron microscopes to diagnose pathological conditions (particularly Primary Ciliary Dyskinesia), I support research in several areas, and I am also involved in outreach activities for schools and the public.

My part-time PhD project will study three dimensional bone structure in health and disease. I am delighted to have the opportunity to broaden my scientific horizons and use my microscopy experience in this innovative project. I will investigate bone tissue using confocal laser scanning microscopy, high resolution computed tomography and serial block face scanning electron microscopy. Producing three dimensional images and data sets will enable us to understand the structure of bone cells in a new way and hopefully contribute to the understanding of diseases including osteoporosis and osteoarthritis.

My supervisors on this project are Dr Philipp Schneider (Bioengineering, Faculty of Engineering and the Environment), Prof Richard Oreffo (Bone and Joint Research Group, Faculty of Medicine) and Dr Konstantinos Zygalakis (Mathematical Sciences, Faculty of Social, Human & Mathematical Sciences).

2016 Cells & Materials Publication

High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: Insights on bone development, ageing, health and disease

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