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(023) 8120 6107
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D.Boche@soton.ac.uk

Professor Delphine Boche PhD

Professor of Neuroimmunopathology

Professor Delphine Boche's photo

Delphine Boche is a Professor of Neuroimmunopathology within Medicine at the University of Southampton. Her research focuses on understanding neuroinflammation and its consequences in patients affected by neurological disease.  She was the recipient of a European Marie Curie Individual Fellowship (2000) and of a MRC New Investigator Award (2006).

Microglia, the Dr Jekyll and Mr Hyde of the brain

Her main interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the complementary approaches of human brain analysis and animal models. Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed expertise in clinical neuroimmunopathology.

She serves on: (i) international grant review boards: Canadian Weston Brain Institute, US Alzheimer’s Association; (ii) international editorial boards: Neuropathology and Applied Neurobiology, Scientific Reports; (iii) international conference committees: US Alzheimer’s Association, Scientific Program, International Society to Advance Alzheimer's Research and Treatment (ISTAART); (iv) grant review boards: Alzheimer’s Research UK, Alzheimer’s Society PhD board.  Delphine sits on the Brains for Dementia Research Steering Committee and the Cambridge Brain Bank Committee, and she is the external examiner for the MSc in Translational Pathology (Neuroscience) for Sheffield University.  In 2014, as the co-chair of the Southampton Neuroscience Group (SoNG) - a platform for collaborative, interdisciplinary and applied neuroscience- she initiated the Spring Event and Prizes for the best neuroscience project delivered by an undergraduate and a master’s students.

 

Qualifications

BSc Cell Biology and Physiology, University Paris 12, France (1991)
MSc Cell Biology, University Paris 12, France (1992)
MRes Neurosciences, College de France and University 6, France (1993)
PhD in Neurosciences, University Paris 6, France (1997)
Fellow of the Higher Education Academy, UK (2010)

Appointments held

Bourse Roux (Fellowship) Institut Pasteur Paris (France): 1998-1999
Marie Curie Fellow (European Community), School of Biological Sciences, University of Southampton (UK): 2000-2001
Post-Doctoral Research Fellow, School of Biological Sciences, University of Southampton (UK): 2001-2004
Post-Doctoral Research Fellow, School of Medicine, University of Southampton (UK): 2004-2006
MRC New Investigator, School of Medicine, University of Southampton (UK): 2006-2009
Lecturer, Faculty of Medicine, University of Southampton (UK): 2009 – 2013
Associate Professor, Faculty of Medicine, University of Southampton (UK): 2013-2017
Professor of Neuroimmunopathology, Faculty of Medicine, University of Southampton (UK): 2017-present

Research interests

Delphine serves as PI and Co-PI on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.  Her research investigates the role of microglia, the resident macrophage-like cells of the brain, in neurodegenerative diseases using the complementary approaches of human brain tissue analysis and animal models. 

 

Immunophenotyping microglia in neurological conditions such as: Alzheimer’s disease, dementia with Lewy bodies, schizophrenia, glioblastoma
Neuroinflammation in age-related dementia
Exploring the impact of systemic inflammation on microglial phenotype and brain pathology
Ab immunotherapy in human Alzheimer’s disease

Research group

Clinical and Experimental Sciences

Affiliate research group

Clinical Neuroscience Research group

International grant review boards
  • Canadian Weston Brain Institute, grant review panel (2015 on)
  • US Alzheimer’s Association, Canadian Weston Brain Institute and Alzheimer’s Research UK joint grant review panel for “Mechanisms of Cellular Death in Neurodegeneration” (MCDN) call (2015)
International editorial boards
  • Scientific Reports (Neurology, Nature Publishing Group), Editorial Board (2015 on)
  • Neuropathology and Applied Neurobiology, Editorial Board (2015 on)
  • Brain Pathology, Senior Editor, special review issue on the “Inflammasome” (2017)
  • Neuropathology and Applied Neurobiology,  Guest Editor, special review issue on “Neuroinflammation in ageing and neurodegenerative disease” (2013)
International conference committees
  • US Alzheimer’s Association, Scientific Program Committee, International Conference (2017 on)
  • US Alzheimer's Association, International Society to Advance Alzheimer's Research and Treatment (ISTAART), Executive Committee member of the Professional Interest Area “Immunity and Neurodegeneration” (2015 on)
  • The Alzheimer’s Disease Congress, Advisory Board (2014-2015)
International (other activities)
  • Nominated expert for: US Alzheimer’s Association; France Alzheimer; “Agence Nationale de la Recherche”; Israel Science Foundation; Research Foundation Flanders (FWO) (2010 on)
  • European Alzheimer’s Disease Consortium, Southampton lead (2013 on)
  • Peer review for international journals including: Acta Neuropathologica, Brain, Brain Pathology, Brain Behavior and Immunity, Scientific Reports
  • Invited review for Journal of Neural Transmission (2017)
  • International Conference on Alzheimer’s Disease (ICAD), selected for media/press presentation (2010)
National grant review boards
  • Alzheimer’s Research UK, Grant Review Board (2016 on)
  • Alzheimer’s Society UK, PhD review panel (2015 on)
  • Nominated expert for: the Medical Research Council; Parkinson UK; Dementia consortium (Alzheimer’s Research UK, AbbVie, Astex, Eisai, Lilly, MRC Technology) (2015 on)
National examining
  • External Examiner, MSc in Translational Pathology (Neuroscience), Faculty of Medicine, Dentistry and Health, University of Sheffield (2015 on)
National administration
  • UK Brains for Dementia Research, Steering Committee member (2014 on)
  • University of Cambridge, Brain Bank Committee member (2014 on)
  • Alzheimer’s Research UK National Network, South Coast Regional Chair (2008-2014), included hosting national conference in Southampton (2010)
Local
  • University of Southampton, Southampton Neurosciences Group (SoNG), co-chair, (2013-2016)
  • University of Southampton, Research Exercise Framework, submission of Impact Statement, 2013
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Articles

Book Chapters

Conferences

Review

BM5. Lectures on the Locomotor & Nervous Systems Courses

BM4/SSU1/HCSW. Facilitator

BIOL3037/BIOL6038 Immunology. Lectures on Neuroimmunology

BMedSc/MMedSc. project supervisor

BIOL6067. Lectures on human neuropathology in dementia and use of human samples

Professor Delphine Boche
Faculty of Medicine Clinical and Experimental Sciences University of Southampton Southampton General Hospital Mailpoint 806 Southampton SO16 6YD

Room Number: SGH/LD72/MP806

Facsimile: (023) 8120 6085

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