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The University of Southampton
Institute for Life Sciences

11th Bioengineering Sciences Seminar Event

21 September 2012
Room 2207, Life Sciences Building (85), Highfield Campus, University of Southampton, University Road, SO17 1BJ

For more information regarding this event, please email Nick Evans at .

Event details

"Cells, cell sheets and insect embryos: modelling the role of mechanics in tissue development" Dr Carina Dunlop, University of Surrey.

It is becoming increasingly clear that mechanical interactions play a crucial role in controlling cellular behaviours in development and morphogenesis. However, it is often unclear how we can use these observations at the cell-level to understand the development of entire tissues. In particular inferring cellular behaviour from tissue-level experimental observations is complicated due to the multiple interactions and feedbacks that are dynamically occurring between cells and their microenvironments I will here demonstrate two different approaches. In the first, individual based simulations are used to tackle the problem from the bottom-up by postulating individual cell behaviours before ‘growing' the tissue in silico. The second adopts a top-down approach using a continuum description of the whole tissue which is integrated with mechanical models for individual cellular behaviour. These models are used to explain cellular self-organization in the paradigm developmental system of Drosophila melanogaster and to infer individual cellular force generation from traction force assays.

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