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The University of Southampton
Institute for Life Sciences

11th Bioengineering Sciences Seminar Event

Time:
14:00
Date:
21 September 2012
Venue:
Room 2207, Life Sciences Building (85), Highfield Campus, University of Southampton, University Road, SO17 1BJ

For more information regarding this event, please email Nick Evans at N.D.Evans@soton.ac.uk .

Event details

"Cells, cell sheets and insect embryos: modelling the role of mechanics in tissue development" Dr Carina Dunlop, University of Surrey.

It is becoming increasingly clear that mechanical interactions play a crucial role in controlling cellular behaviours in development and morphogenesis. However, it is often unclear how we can use these observations at the cell-level to understand the development of entire tissues. In particular inferring cellular behaviour from tissue-level experimental observations is complicated due to the multiple interactions and feedbacks that are dynamically occurring between cells and their microenvironments I will here demonstrate two different approaches. In the first, individual based simulations are used to tackle the problem from the bottom-up by postulating individual cell behaviours before ‘growing' the tissue in silico. The second adopts a top-down approach using a continuum description of the whole tissue which is integrated with mechanical models for individual cellular behaviour. These models are used to explain cellular self-organization in the paradigm developmental system of Drosophila melanogaster and to infer individual cellular force generation from traction force assays.

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