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The University of Southampton
Institute for Life Sciences

Genetic complexity in myeloproliferative neoplasms Seminar

13:00 - 14:00
28 February 2013
Lecture Theatre, Level A, Institute of Developmental Sciences, Southampton General Hospital, Tremona Rd, Southampton, Hampshire S016 6YD

For more information regarding this seminar, please email Robert Murray at .

Event details

HDH Seminar

Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid cell lineages in the bone marrow and increased numbers of mature and immature cells in the peripheral blood. Several subtypes of MPN have been defined with variable morbidity and mortality as a consequence of increased risk of thrombosis, transformation to acute leukaemia and other causes. We have taken several approaches to identify somatically mutated genes in MPN, including characterisation of translocations, DNA arrays and exome sequencing. Several new oncogenes and tumour suppressor genes have been identified, some of which are strong prognostic indicators. Overall our findings indicate a complex interplay between defects in signalling pathways, transcription factors and epigenetic regulators in the pathogenesis of MPN. Several somatically mutated genes are also mutated in human developmental disorders thus pointing towards a remarkable and unexpected convergence between somatic and germline genetics.

Speaker information

Prof. Nick Cross,University of Southampton, Director of Wessex Regional Genetics Laboratory

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