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The University of Southampton
Institute for Life Sciences

Bioengineering Sciences Seminar Series Event

Time:
12:00 - 13:00
Date:
21 February 2014
Venue:
Room 2207 Life Sciences Building (85) Highfield Campus

For more information regarding this event, please email Dr Nick Evans at N.D.Evans@soton.ac.uk .

Event details

“Material-driven protein assembly to engineer the cellular microenvironment”

Most cells assemble rich protein matrices via an integrin-dependent process that incorporates e.g. fibronectin molecules into matrix fibrils. We have shown that this process can occur by simple adsorption of individual protein molecules onto particular surface chemistries – in absence of cells. Fibronectin – material interactions would induce exposure of self-assembly sites to drive FN assembly, a process that we named material-driven fibronectin fibrillogenesis.

The resulting FN matrix assembled at the material interface consists of a protein (nano)network with enhanced biological activity: it supports cell adhesion, matrix remodelling, and trigger cell differentiation. Moreover, it provides a robust platform to engineer advanced microenvironments in combination with growth factors to tune stem cell differentiation and promote tissue repair.

Speaker information

Professor Manuel Salmeron,School of Engineering,University of Glasgow

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