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The University of Southampton
Institute for Life Sciences

Seminar: Customized biomaterials through precise molecular engineering Event

Cells on ceramic crystals
13:00 - 14:00
16 September 2016
University of Southampton, Highfield Campus, Building 05, Room 2011

For more information regarding this event, please email Dario Carugo and Laura Cooper at .

Event details

A lecture by Helena S. Azevedo of Queen Mary University London in the University of Southampton Bioengineering Seminar Series.


Abstract: Molecular self-assembly is becoming increasingly important in the development of innovative biomaterials because it offers a great platform for fabricating them with a high level of precision and complexity. A number of building blocks have been explored for developing self-assembling biomaterials, but peptides offer many important advantages. They can be designed to incorporate structural and bioactive domains and form discrete nanostructures that emulate not only the physical architecture but also the chemistry of the extracellular matrix. Through rational design, our group is integrating interacting domains into peptides to drive their self-assembly into well-defined structures and provide signals for cells to adhere, spread or differentiate. This talk will cover our work on the molecular design of biomaterials (membranes, capsules, hydrogels) customized for specific biomedical applications (skin wound healing, cell culture) but also our recent developments on periosteum-like membranes and nanocarriers for targeted intracellular delivery.

Selected publications:

  1. A.C. Mendes, E.T. Baran, R.L. Reis, H.S. Azevedo, WIREs Nanomed & Nanobiotechnol 2013, 5: 582-583.
  2. D.S. Ferreira, Y.-A. Lin, H. Cui, J.A. Hubbell, R.L. Reis, H.S. Azevedo. Adv. Healthcare Mater 2015, 4: 602-612.
  3. A.C. Mendes, K.H. Smith, E. Tejeda-Montes, E. Engel, R.L. Reis, H.S. Azevedo, A. Mata, Adv. Funct. Mater 2013, 23: 430-438.
  4. D.S. Ferreira, A.P. Marques, R.L. Reis, H.S. Azevedo, Biomaterials Sci. 2013, 1: 952-964.
  5. D.S. Ferreira, R.L. Reis, H.S. Azevedo, Soft Matter 2013, 9: 9237-9248.
  6. R.M. Capito, H.S. Azevedo, Y.S. Velichko, A. Mata, S.I. Stupp, Science 2008, 319: 1812-1816.

Image credit: Karen Hing, Wellcome Images, cells on ceramic crystals, reproduced under Creative Commons licence 4.0.

Speaker information

Dr Helena S. Azevedo,Queen Mary University of London,Senior Lecturer in Biomedical Engineering & Biomaterials / Institute of Bioengineering Director of Operations. IoB Highlights: Self-assembling hyaluronan-peptide biomaterials Key strengths: Peptide discovery (phage display) and design, peptide chemistry (synthesis, characterization), hyaluronan (HA)/peptide interactions, self-assembling biomaterials (membranes, capsules, hydrogels) and cell encapsulation

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