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The University of Southampton
Institute for Life Sciences

Shedding light on tumor metabolism: new imaging methods to probe oxygen supply and demand Event

Dr Sarah Bohndiek
Time:
12:00 - 13:00
Date:
28 October 2016
Venue:
Building 07, Room 3019, University of Southampton, Highfield Campus, Southampton, SO17 1BJ

For more information regarding this event, please email Dario Carugo or Laura Cooper at D.Carugo@soton.ac.uk or Laura.Cooper@soton.ac.uk .

Event details

A lecture in the Bioengineering Seminar Series presented by Dr Sarah Bohndiek, University of Cambridge

 

Abstract: Oxidative stress and metabolic alterations derived from inflammation and tumor growth lead to hypoxia and angiogenesis in cancer and are associated with disease aggressiveness as well as the evolution of drug resistance. There are few validated, non-invasive, methods to detect the spatiotemporal distribution of these processes. To overcome this limitation, we aim to create and apply novel imaging methods to study oxygen delivery and utilization in preclinical models and in patients. In this talk, I will give an overview of how biomedical optics can aid this research effort and focus on two emerging approaches: optoacoustic and hyperspectral imaging, detailing both their technological development as well as giving examples of their biomedical application in living subjects.

Speaker information

Dr Sarah Bohndiek,Department of Physics and Cancer Research UK Cambridge Institute, University of Cambridge,Brief Biography: Dr Sarah Bohndiek completed her PhD in Radiation Physics at University College London in 2008 and then worked in both the UK and the USA as a postdoctoral fellow in molecular imaging. Since 2013, she has led the VISION laboratory at the University of Cambridge, developing new techniques for spectral imaging of oxygen and oxidative stress in cancer. These techniques have been applied to study both disease development and the emergence of drug resistance and are now translating into the clinic. Sarah has published over 30 research articles on molecular imaging of cancer, which have received over 1000 citations. She was awarded the Institute of Physics Paterson Medal, WISE Research Award and MSCA Prize in 2014 recognition of this work.

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