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The University of Southampton
Institute for Life Sciences

Hematopoietic Stem Cell Dormancy, Proliferation and Memory Event

Jeffrey Bernitz
Time:
14:00 - 15:00
Date:
13 December 2016
Venue:
Room 2207, Building 85, Highfield Campus, University of Southampton

For more information regarding this event, please email Dr Ben MacArthur at IfLSAdmin@soton.ac.uk .

Event details

Presented by visiting speaker Jeff Bernitz of the Icahn School of Medicine, NY.

 

Abstract: Hematopoietic stem cell (HSC) transplantations are used to treat a wide variety of hematological and non-hematological disorders. However, a major barrier to their widespread clinical use is limited donor stem cell numbers for transplantation. To combat this issue, HSC expansion for therapeutic use has been a major clinical effort for decades. Unfortunately most attempts have met with minimal success, as enforcing HSC proliferation ex vivo has led to functional decline of these cells upon transplantation. To better understand how HSC proliferation impacts HSC regenerative potential, we use a transgenic mouse model that allows us to track the divisional history of HSCs over time in vivo. Work with this model showed that progressive accumulation of cell divisions result in the progressive loss of HSC regenerative potential, and that HSCs count and maintain a memory of their cell division events over time. Most recently, we have examined HSCs in various proliferative contexts. This work shows that the memory can be "reset" and will help to dissect the underlying molecular mechanisms regulating this cell division counter.

Speaker information

Jeff Bernitz,Icahn School of Medicine, New York,.

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