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The University of Southampton
Institute for Life Sciences

Bioengineering Seminar: Controlling Molecular Transport in Skin Membrane using Microneedles Event

27 April 2017
Room 3023, Building 7, Highfield Campus

For more information regarding this event, please email Dr Dario Carugo at .

Event details

Bioengineering Seminar with speaker Dr Diganta Bhusan Das, Loughborough University

Controlling Molecular Transport in Skin Membrane using Microneedles

Abstract: Microneedle is a promising technique for delivering a variety of drugs across skin. The microneedles were originally designed to mimic the mosquito sting as a way of minimally invasive method of transdermal drug delivery. The technique can offer a number of benefits over other drug delivery methods. For example, the drugs only diffuse over a short distance before reaching the blood circulation which enhances the absorption of drugs by the tissue. However, the drug transport behaviour in skin is affected by a complex interplay of different parameters (e.g., microneedle geometries, permeability across skin, etc). The present talk will explore the importance of these variables by using a combination of modelling and experimental techniques. Furthermore, it will discuss the key manufacturing techniques for microneedles as well as demonstrate their efficacy in controlled release of drug molecules. Issues such as microneedle penetration, skin viscoelasticity and properties of the drug formulation (e.g., drugs in suspension or loaded on particles) will also be discussed.


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