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The University of Southampton
Institute for Life Sciences

Liposomal drug delivery: a journey from fundamentals to recent advances Event

Time:
11:00 - 12:00
Date:
11 April 2018
Venue:
General Hospital, IDLS Building/ Lecture Theatre (Level A)

For more information regarding this event, please email Dr Dario Carugo at D.Carugo@soton.ac.uk .

Event details

Joint Talk by Dr Wayne Nishio Aire (Cardiff University, UK) and Prof Claudio Nastruzzi (University of Ferrara, Italy)

 

Abstracts

Prof Wayne Nishio Aire -Liposomal delivery systems for orthopaedic and dental applications

Liposomes are vesicles consisting of a bilayer of lipid molecules which enclose an aqueous space.  Their use as drug carriers dates back to the early 1970s and they have since been widely implemented for the delivery of anti-cancer drugs, antimicrobials, chelating agents, steroids, vaccines, proteins and genetic material.  This is owed to their biocompatibility, long circulation time, ability to encapsulate both hydrophilic and hydrophobic therapeutics and ability to be tailored in terms of size, charge and composition.  Existing methods to deliver therapeutics from orthopaedic and dental materials (e.g. bone cements and implant coatings) are limited and often suffer from poor release characteristics, reduced mechanical properties and usually require high doses to achieve therapeutic effects.  This talk focuses on how our research group has used liposomes to overcome these limitations for a range of biomaterials.  In particular how liposomes have been used in: orthopaedic bone cement to double the amount of gentamicin sulphate gradually released over 60 days; dental glass ionomer cements to allow the release of triclosan, a highly hydrophobic antimicrobial; increase the wear resistance of carbon-fibre reinforced PEEK acetabular cups; and enhance the osseointegration of titanium implants.  The talk will also reflect on some lessons learned on the route to translation and exciting future developments in this area of research.

 

 

Prof Claudio Nastruzzi - Preparation, characterization and applications of liposomes in pharmaceutics

The talk will be mainly focused on the description of “vesicles”, also known as “liposomes” (terms used to designate a particular type of compartment, formed in vitro in an aqueous medium by amphiphilic molecules).

The basic principles of liposome structures and preparations, will be provided, describing the key concepts of currently known methods for preparing liposomes and their advantages and disadvantages. In addition, the description of some aspect regarding the evaluation parameters of liposomal formulation will be discussed, such as the encapsulation of drugs, the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use.

The final part of the talk will be devoted to the description of a relatively new approach for the production of different nanoscale lipid-based vesicular systems. The use of microfluidic techniques will be discussed, analyzing the critical issues associated with the production of liposomes.

 

Speaker information

Prof Wayne Nishio Ayre ,Cardiff University, UK,Prof Wayne Nishio Ayre - Dr Ayre graduated from Cardiff University in 2009 with a bachelor in Medical Engineering. He obtained his PhD in Mechanical Engineering in 2013 under the supervision of Prof Sam Evans and Prof Stephen Denyer as part of the Arthritis Research UK Biomechanics and Bioengineering Centre of excellence at Cardiff. The project was a collaboration between the Schools of Engineering and Pharmacy and focused on enhancing antibiotic delivery from orthopaedic bone cement using liposomes. The novel liposomal delivery system was patented in 2014 and is in the early stages of clinical translation. After a short research assistant post working on carbon fibre composites for aerospace applications, Dr Ayre moved to the Cardiff School of Dentistry as a post-doctoral researcher, applying his knowledge of materials and drug delivery to develop novel antimicrobial restorative dental materials. In 2016 he was appointed as a Lecturer in Biomaterials at the School of Dentistry. During his research career Dr Ayre has secured just over £1M in research funding from sources such as NIHR, Welsh Government, Dunhill Medical Trust, Wellcome Trust and the MRC. He works closely with industry (Renishaw, Philips and Zimmer Biomet) and has been the recipient of several prizes such as the Worshipful Company of Engineers Mercia Award, the IADR-PER GSK/MINTIG prize, the CITER Young Investigator of the Year award and the BORS International Travelling Fellowship.

Prof Claudio Nastruzzi,University of Ferrara, Italy,Prof Claudio Nastruzzi- Claudio Nastruzzi was born in Ferrara on March 29, 1958. 1983 - Degree in Pharmaceutical Chemistry at the University of Ferrara, Department of Pharmaceutical Science. 1983-1984 - Fellow in the Department of Pharmaceutical Science of University of Ferrara, working on natural compound synthesis (prostaglandins and leukotriens) and characterization of isosazolic and isosazolinic nuclei reactivity. 1988 - Ph.D. in Pharmaceutical Science, with a dissertation on the syntesis, antitumor and antimetastatic activity of aromatic polyamidines. 1988-1990 - Post-doctoral position at the Institute for Polymers of the Eidgenissische Technische Hochschule, (Swiss Federal Institute of Technology) (ETH), Zürich in the group of Prof. P.L. Luisi. 1990-1991 - Post-doctoral position at the Department of Pharmaceutical Sciences of the University of Ferrara, having as main topic the production and characterization of liposomes especially designed for retinoids delivery. Biophysical studies and activity on in vitro cultured cell lines. 1991-1998 - Researcher position at the Department of Pharmaceutical Sciences of the University of Ferrara, investigating the production of microspheres, liposomes and microemulsions for the controlled delivery of biological response modifiers. 1998-2009 - Associated Professor at the Dipartimento di Chimica e Tecnologia del Farmaco, of the University of Perugia, Perugia, Italy. 2009-2012 - Associated Professor at the Dipartimento di Scienze Farmaceutiche, of the University of Ferrara, Ferrara, Italy. 2012-Present - Associated Professor at the Dipartimento di Scienze della Vita e Biotecnologie, of the University of Ferrara, Ferrara, Italy. Research activity In 2002, Claudio Nastruzzi started the activity of the Laboratory of Biomaterials & Encapsulation (BEL). The main goal of the Laboratory is an integrative concept of research and teaching in the fields of biomaterials, bioencapsulation, drug formulation and drug delivery. Currently are under investigation different formulations including, inorganic matrixes, liposomes, lipospheres, microparticles, nanocapsules, microemulsions and polymeric films. For the development of such delivery systems we are in close cooperation with other groups in the basic, engineering, medical sciences and pharmaceutical industry. Another important field of study of BEL is represented by cell encapsulation and transplantation using natural, synthetic and engineerized polymers. The research group focuses on the development of biomaterials and delivery systems for drugs, biological response modifiers, biotech products and cosmetics. Production and characterization of particulate delivery systems is investigated, including liposomes and microspheres for gene therapy. In particular, new formulations, have been designed and produced for Natural and Peptide (PNA) Nucleic Acids, based on cationic polymeric sub-micron particles constituted by Eudragit RS 100 plus different cationic surfactants such as dioctadecyl-dimethyl-ammonium bromide (DDAB18) and diisobutylphenoxyethyl dimethylbenzyl ammonium chloride (DEBDA). Moreover, the design and production of advanced cosmetic formulations has been accomplished, based on liquid crystals, microparticles in association with hydrophilic polymers and polymeric surfactants. The laboratory has also expertise in tissue engineering and cell encapsulation protocols (pancreatic islets, Sertoli cells, osteoblasts, etc.) and biocompatibility tests for the validation of biomaterials. The rapid prototyping section focuses on the design and development of small laboratory equipments for biotech applications and microencapsulation protocols. Finally, the laboratory know-how has expanded to the design, production and use of microfluidic chip for the production of nanoparticles and microparticles. Claudio Nastruzzi has published more than 200 papersand presented more than 150 contributions to national and international conferences.Istitutional Activity 1. Responsabile del Dipartimento di Scienze della Vita e Biotecnologie per i servizi informatici e la realizzazione e gestione del sito dipartimentale (Ferrara, 2011-2014). 2. Membro della Commissione Ricerca del Dipartimento Scienze della Vita e Biotecnologie (Ferrara, 2011-2014). 3. Rappresentante di Ateneo per il Consorzio Interuniversitario Nazionale di Tecnologie Farmaceutiche Innovative (TEFARCO Innova) (Ferrara, Parma, 2011-2014). 4. Reponsabile Unità Operativa del Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM) (Ferrara, 2011-2014). 5. Reponsabile Unità Operativa del Consorzio Interuniversitario Nazionale per le Biotecnologie (CIB) (Ferrara, 2011-2014). 6. Rappresentante italiano del Management Committee per l’Azione COST Materials, Physical and Nanosciences COST Action MP0603 (Chemical imaging by means of CARS-microscopy (MicroCARS). (Ferrara, Bruxelles, 2007-2011). 7. Rappresentante italiano del Management Committee per l’Azione COST Biomedicine and Molecular Biosciences COST Action BM1302 (Joining Forces in Corneal Regeneration Research). (Ferrara, Bruxelles, 2013-2017). 8. Docente per il corso di Tecnologie Farmaceutiche per il Master Executive in “Pharmacy Management”, ALTEMS (Alta Scuola di Economia e Management dei Sistemi Sanitari) dell’Università Cattolica del Sacro Cuore (Roma 2012). 9. Membro del Collegio Docenti del Dottorato di Ricerca in “Scienze del farmaco, delle biomolecole e dei prodotti per la salute”, Università di Parma. Web-based Resources and Info: ReasearcherID: www.researcherid.com/rid/N-4230-2015, Laboratory web page: www.biomaterials.it

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