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The University of Southampton
Institute for Life Sciences

Implementing basic to clinical science: The discovery of novel biomarkers to potentially minimize overdiagnosis and overtreatment of prostate cancer Seminar

Biological Sciences
29 October 2012
Building 85 Room 2207

For more information regarding this seminar, please telephone Beatrice Murphy on 023 8059 5374 or email .

Event details

The current gold standard clinical test for prostate cancer (prostate specific antigen; PSA) is flawed. A recent study on prostate cancer sufferers in the US has found that the commonly used PSA cut off value of 4.1 ng/mL would have a sensitivity of only 20.5% (would identify only 1/5th of prostate cancer sufferers) and would identify only 40% of men with aggressive disease, based on histopathologically determined Gleason score.

We have compared the blood protein levels at different stages of prostatic disease progression against healthy volunteers that led to the identification of proteins that stratified this disease progression, above and beyond PSA. As such, these could be important as markers to distinguish between slow growing prostate cancer and aggressive prostate cancer. On-going validation studies will ensure that the proteins identified in the first stage are indeed important in prostate cancer progression or the body’s response to prostate cancer and its therapeutic intervention. The results are potentially transferable to the wider population affected by prostate cancer as these stages will verify that we have identified a clinically relevant marker of prostate cancer progression. An exciting opportunity exists for all clinical diagnostic companies to improve diagnosis. Moreover, mis-diagnosed PSA caused financial and psychological trauma. A number of invasive tests for PrCa are not needed, consequences with regards to undue anxiety, infections, trauma and healthcare is immense, costing the NHS in the UK alone.

Dr Spiros D. Garbis

Speaker information

Dr Spiros D. Garbis,Centre for Proteomics & Metabolomics Research, Faculty of Medicine

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